Interoceptive and multimodal functions of the operculo-insular cortex: Tactile, nociceptive and vestibular representations
Interoceptive and multimodal functions of the operculo-insular cortex: Tactile, nociceptive and vestibular representations
复制标题
DOI：
10.1016/j.neuroimage.2013.06.057
复制
发表时间：
2013-12-01
期刊：
影响因子：
5.7
通讯作者：
Dieterich, M.
中科院分区：
文献类型：
--
作者：
Eulenburg, P. Zu;Baumgaertner, U.;Dieterich, M.
盖岛皮层被称为人类大脑的“自我平衡控制中心”或“一般大小估计器”。在这项研究中，躯体感觉，伤害性和热量前庭刺激，以揭示，是否有主要共同的，或可能是特定的区域激活的一种方式单独和是否偏侧化效应，时间模式的差异或影响的厌恶性质的刺激可以观察到。激活的背后额叶是由所有的刺激一样，从而terning这一领域的多模式。有害热和热量前庭刺激的早期阶段导致前额叶的反应。使用连接分析，我们发现，左侧和右侧的触觉刺激，但不是伤害性刺激，引起的联合激活的cytoarchitectonic区OP 1和伤害性，但不是触觉刺激的前额叶双侧。顶骨盖（SII，OP 1）的触觉激活与伤害性激活（OP 3和额盖）不同，位于背后角的三种刺激的联合激活证明了多感觉结构的存在。厌恶性刺激和多感觉信号的后额叶前部的不同激活支持了最近基于连通性研究和荟萃分析引入的分区岛叶皮层的概念。(C)2013 Elsevier Inc. All rights reserved.
The operculo-insular cortex has been termed the 'homeostatic control center' or 'general magnitude estimator' of the human mind. In this study, somatosensory, nociceptive and caloric vestibular stimuli were applied to reveal, whether there are mainly common, or possibly specific regions activated by one modality alone and whether lateralization effects, time pattern differences or influences of the aversive nature of the stimuli could be observed.Activation of the dorsal posterior insula was caused by all stimuli alike thus terming this area multimodal. Early phases of the noxious heat and caloric vestibular stimulation led to responses in the anterior insula. Using conjunction analyses we found that left- and right-sided tactile stimulation, but not nociceptive stimulation, caused a joint activation of the cytoarchitectonic area OP1 and nociceptive but not tactile stimulation of the anterior insula bilaterally. Tactile activation in the parietal operculum (SII, OP1) was distinct from nociceptive activation (OP3 and frontal operculum).The joint activation by all three stimuli located in the dorsal posterior insula argues for the presence of multisensory structures. The distinct activation of the anterior insula by aversive stimuli and the posterior insula by multisensory signals supports the concept of a partitioned insular cortex recently introduced based on connectivity studies and meta-analyses. (C) 2013 Elsevier Inc. All rights reserved.