Vaccine assembly from surface proteins of Staphylococcus aureus
Vaccine assembly from surface proteins of Staphylococcus aureus
复制标题
DOI：
10.1073/pnas.0606863103
复制
发表时间：
2006-11-07
影响因子：
11.1
通讯作者：
Schneewind, Olaf
中科院分区：
文献类型：
--
作者：
Stranger-Jones, Yukiko K.;Bae, Taeok;Schneewind, Olaf
金黄色葡萄球菌是医院获得性感染的最常见原因。由于抗生素耐药菌株的出现，这些感染代表了严重的公共卫生威胁。为了开发一种具有广泛保护性的疫苗，我们测试了S.金黄色葡萄球菌作为脓肿形成的小鼠模型中的抗原。用四种抗原（IsdA，IsdB，ScIrD和SdrE）免疫产生与调理吞噬抗体诱导相关的显著保护性免疫。当组装成联合疫苗时，这四种表面蛋白提供了高水平的保护，以对抗侵袭性疾病或人类临床沙门氏菌的致命攻击。金黄色葡萄球菌分离株
Staphylococcus aureus is the most common cause of hospital-acquired infection. Because of the emergence of anti biotic-resistant strains, these infections represent a serious public health threat. To develop a broadly protective vaccine, we tested cell wall-anchored surface proteins of S. aureus as antigens in a murine model of abscess formation. Immunization with four antigens (IsdA, IsdB, ScIrD, and SdrE) generated significant protective immunity that correlated with the induction of opsonophagocytic antibodies. When assembled into a combined vaccine, the four surface proteins afforded high levels of protection against invasive disease or lethal challenge with human clinical S. aureus isolates.