PERINATAL HYPOTHYROIDISM IN RATS - PERSISTENT MOTIVATIONAL AND METABOLIC EFFECTS
PERINATAL HYPOTHYROIDISM IN RATS - PERSISTENT MOTIVATIONAL AND METABOLIC EFFECTS
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DOI：
10.1002/dev.420090110
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发表时间：
1976-01-01
影响因子：
2.2
通讯作者：
HENNIES, RS
中科院分区：
文献类型：
--
作者：
DAVENPORT, JW;HENNIES, RS
五组雌性大鼠暴露于硫氧嘧啶不同时期的出生时间进行了比较，一组未经处理的控制在青春期和成年期的动机，代谢和激素测试的情况。硫氧嘧啶处理的大鼠表现出减少恐惧的触摸和按压任务在操作性条件反射室，并在其最初的适应活动轮和迷宫装置。这些大鼠还表现出多动的渐近转轮性能，增加自发恢复熄灭的压和升高响应压可变间隔食物强化。一项补充研究显示，雄性硫氧嘧啶治疗大鼠的随意食物和水摄入量和O2消耗量显着增加，硫氧嘧啶治疗雌性大鼠的血清甲状腺素水平升高。围产期甲状腺缺乏症在两种性别中均引起慢性高代谢状态，这可能与雌性大鼠的持续性轻度甲状腺功能亢进症相关。
Five groups of female rats exposed to thiouracil for varying periods around the time of birth were compared with a group of untreated controls in motivational, metabolic and hormonal test situations during adolescence and adulthood. The thiouracil-treated rats displayed reduced fearfulness in lever-touching and lever-pressing tasks in operant conditioning chambers and in their initial adaptation to activity-wheel and maze apparatuses. These rats also showed hyperactivity in asymptotic running-wheel performance, increased spontaneous recovery of extinguished lever-pressing and elevated responding in lever-pressing for variable-interval food reinforcement. A supplemental study revealed significantly greater ad lib food and water intake and O2 consumption in male thiouracil-treated rats and elevated serum thyroxine levels in thiouracil-treated females. Perinatal thyroid deficiency engenders a chronic hypermetabolic state in both sexes which may be associated with a persistent, mild hyperthyroid condition in the case of female rats.