Fat mass is positively associated with bone mass in relatively thin adolescents: Data from the Kitakata Kids Health Study
Fat mass is positively associated with bone mass in relatively thin adolescents: Data from the Kitakata Kids Health Study
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DOI：
10.1016/j.bone.2014.04.027
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发表时间：
2014-07-01
期刊：
影响因子：
4.1
通讯作者：
Iki, Masayuki
中科院分区：
文献类型：
--
作者：
Kouda, Katsuyasu;Fujita, Yuki;Iki, Masayuki
流行病学研究发现，体重越重，骨骼越健康。体重由脂肪量（FM）和瘦软组织量（LSTM）组成。以前的研究已经检查了儿童时期FM水平对骨骼健康的影响，结果相互矛盾。在本研究中，我们调查了FM对日本青少年骨量的独立贡献。研究对象为2010年8月和2013年8月来自日本Kitakata儿童健康研究的235名15-18岁青少年。我们获得了身体成分和骨密度（BMD）的横断面数据。使用双能x射线吸收扫描仪测量身体成分和骨密度。我们发现FM指数与LSTM指数呈正相关（男性r = 0.69，女性r = 0.44）。为了验证FM对LSTM之外的骨骼变量方差的潜在加性影响，我们通过LSTM指数的分位数分层评估了FM指数与骨骼变量之间的关联。在LSTM指数最低分蘖中，FM指数与股骨颈骨密度（雄性，β = 0.48，雌性，β = 033）和全身BMC（雄性，β = 0.41，雌性，β = 0.25）均显著相关（P < 0.05）。另一方面，我们发现在LSTM指数的其他三分位数中，FM指数与骨变量之间没有显著的关联。这些发现表明，FM可以影响相对较瘦的青少年获得高骨量，但对正常体重或超重的青少年没有影响。(C) 2014爱思唯尔公司版权所有。
Epidemiologic studies have found that higher body weight is associated with better bone health. Body weight consists of both fat mass (FM) and lean soft tissue mass (LSTM). Previous studies have examined the effects of FM levels during childhood on bone health, with conflicting results. In the present study, we investigated the independent contributions of FM to bone mass in Japanese adolescents. Subjects were 235 adolescents aged 15-18 years old in August 2010 and in August 2013 from the Kitakata Kids Health Study in Japan. We obtained cross-sectional data on body composition as well as bone mineral density (BMD). Body composition and BMD were measured using a dual-energy X-ray absorptiometry scanner. We found moderate and positive relationships between FM index and LSTM index (males, r = 0.69; females, r = 0.44). To verify a potentially additive effect of FM on the variance of bone variables beyond LSTM, we assessed the association between FM index and bone variables after stratification by tertiles of the LSTM index. In the lowest tertile of the LSTM index, FM index was significantly (P < 0.05) associated with both femoral neck BMD (males, beta = 0.48; females, beta = 033) and whole body BMC (males, beta = 0.41; females, beta = 0.25). On the other hand, we found no significant associations between FM index and bone variables in other tertiles of the LSTM index. These findings indicate that FM can influence how high bone mass is obtained among relatively thin adolescents, but not among those who are of normal weight or overweight. (C) 2014 Elsevier Inc. All rights reserved.