Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis
Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis
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DOI：
10.1007/s00198-005-1840-5
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发表时间：
2005-10-01
影响因子：
4
通讯作者：
Kim, GS
中科院分区：
文献类型：
--
作者：
Koh, JM;Khang, YH;Kim, GS
参与炎症的因素与骨重建的关键因素有关。我们研究了健康女性血清高敏C反应蛋白（hsCRP）水平与骨密度（BMD）之间的关系。在30岁或以上的绝经前（n = 3，662）和绝经后（n = 1，031）女性中测量hsCRP和总碱性磷酸酶（ALP）的血清浓度。采用双能X线骨密度仪测量股骨颈和腰椎的BMD。根据WHO定义，骨质减少在-2.5 < T -评分时被诊断为骨质减少。
Factors involved in inflammation are linked with those critical for bone remodeling. We examined the association between serum high sensitivity C-reactive protein (hsCRP) levels and bone mineral density (BMD) in healthy women. Serum concentrations of hsCRP and total alkaline phosphatase (ALP) were measured in premenopausal (n =3,662) and postmenopausal (n =1,031) women aged 30 years or older. BMD was measured at the femoral neck and lumbar spine using dual energy X-ray absorptiometry. According to the WHO definition, osteopenia was diagnosed at -2.5 < T -score