Preoperative Albumin-Bilirubin Score for Postoperative Solitary Hepatocellular Carcinoma within the Milan Criteria and Child-Pugh A Cirrhosis.
Preoperative Albumin-Bilirubin Score for Postoperative Solitary Hepatocellular Carcinoma within the Milan Criteria and Child-Pugh A Cirrhosis.
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米兰标准内的术后孤立性肝细胞癌术前白蛋白-胆红素评分和 Child-Pugh A 型肝硬化。
DOI：
10.7150/jca.21313
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发表时间：
2017
影响因子：
3.9
通讯作者：
Fan J
中科院分区：
文献类型：
--
作者：
Dong ZR;Zou J;Sun D;Shi GM;Ke AW;Cai JB;Sun HC;Qiu SJ;Li T;Zhou J;Zhi XT;Fan J
手术切除仍然是大多数早期肝细胞癌患者的首选治疗方法。尽管影响术后肝细胞癌患者预后的因素已被很好地阐明，但对于符合米兰标准的孤立性肝细胞癌和Child-Pugh(C-P)A级肝硬变患者的术后生存估计，仍有一些简单、客观和独特的方法。白蛋白胆红素(ALBI)评分是一种新的循证评估肝功能的方法。Albi评分消除了主观变量，如腹水和脑病，这些都是传统C-P分级系统的要求。这项研究招募了654名患者，以确定ALBI评分是否可以预测符合米兰标准的孤立性肝细胞癌患者和C-P-A肝硬变患者的术后结果。我们的结果表明，ALBI评分对总生存率和累积复发率有显著影响。此外，在符合米兰标准和C-P-A级的单发肝癌患者中，ALBI评分与肝硬变程度和血清γ-谷氨酰转肽酶浓度显著相关。此外，ALBI评分和血清GGT浓度的组合有助于该队列中的预后预测。总之，我们在外部验证了ALBI分级作为一种新的生物标记物来预测米兰标准范围内的孤立性肝细胞癌和C-P-A肝硬变的预后。
Surgical resection remains the initial treatment of choice for the majority of early stage hepatocellular carcinoma (HCC) patients. Although the factors that influence the prognosis of postoperative HCC patients have been well elucidated, there are a limited number of simple, objective, and distinct methods for estimating survival for postoperative patients with solitary HCC within the Milan criteria and Child-Pugh (C-P) A cirrhosis. The Albumin-Bilirubin (ALBI) score is a new evidence-based approach to assess liver function. The ALBI score eliminates subjective variables, such as ascites and encephalopathy which are the requirements for the conventional C-P grading system. This study enrolled 654 patients to determine whether the ALBI score can predict the outcomes of postoperative solitary HCC patients within the Milan criteria and C-P A cirrhosis. Our results showed the ALBI score significantly influenced the overall survival and cumulative recurrence rates. Furthermore, the ALBI score was significantly related to the degree of liver cirrhosis and serum γ-glutamyl transpeptidase (GGT) concentration in solitary HCC cases within the Milan criteria and C-P A cirrhosis. Additionally, the combination of the ALBI score and serum GGT concentration contributed to the prognosis prediction in this cohort. In conclusion, we externally validated the ALBI grade as a novel biomarker to predict prognosis for solitary HCC within the Milan Criteria and C-P A cirrhosis.
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影响因子：
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作者：
Zhao H;Chen C;Fu X;Yan X;Jia W;Mao L;Jin H;Qiu Y
通讯作者：
Qiu Y
影响因子：
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作者：
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通讯作者：
Hanigan, Marie H.
影响因子：
3.4
作者：
Zhang, T. T.;Zhao, X. Q.;Bai, L.
通讯作者：
Bai, L.
影响因子：
3.9
作者：
Wang XP;Mao MJ;He ZL;Zhang L;Chi PD;Su JR;Dai SQ;Liu WL
通讯作者：
Liu WL
影响因子：
45.3
作者：
Johnson, Philip J.;Berhane, Sarah;Toyoda, Hidenori
通讯作者：
Toyoda, Hidenori