A RISK OF MALIGNANCY INDEX INCORPORATING CA-125, ULTRASOUND AND MENOPAUSAL STATUS FOR THE ACCURATE PREOPERATIVE DIAGNOSIS OF OVARIAN-CANCER
A RISK OF MALIGNANCY INDEX INCORPORATING CA-125, ULTRASOUND AND MENOPAUSAL STATUS FOR THE ACCURATE PREOPERATIVE DIAGNOSIS OF OVARIAN-CANCER
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DOI：
10.1111/j.1471-0528.1990.tb02448.x
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发表时间：
1990-10-01
期刊：
影响因子：
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通讯作者：
GRUDZINSKAS, JG
中科院分区：
文献类型：
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作者：
JACOBS, I;ORAM, D;GRUDZINSKAS, JG
对年龄、超声评分、绝经状态、临床印象评分和血清CA 125水平进行评估，以了解如何最好地区分良性（n = 101）和恶性（n = 42）盆腔肿块患者。单独使用的每一个标准都提供了统计上显著的区别。最有用的个人标准是血清CA 125水平20 U/ml（敏感性81%，特异性75%）和超声评分2（敏感性71%，特异性83%）。恶性肿瘤风险指数（RMI）可以结合三个标准，其简单地使用血清CA 125水平（U/ml）、超声扫描结果（表示为0、1或3分）和绝经状态（如果绝经前为1分，如果绝经后为3分）的乘积来计算。该指数在统计学上实际上与更正式的方法一样有效地区分癌症和良性病变。使用RMI截止值为200，灵敏度为85%，特异性为97%。RMI评分大于200的患者平均患癌症的风险是背景风险的42倍，而评分较低的患者是背景风险的0.15倍。
Age, ultrasound score, menopausal status, a clinical impression score and serum CA 125 level were assessed to see how they could best distinguish between patients with benign (n = 101) and malignant (n = 42) pelvic masses. Each criteria used alone provided statistically significant discrimination. The most useful individual critiera were a serum CA 125 level of 20 U/ml (sensitivity 81%, specificity 75%) and an ultrasound score of 2 (sensitivity 71%, specificity 83%). Three criteria could be combined in a risk of malignancy index (RMI) which is simply calculated using the product of the serum CA 125 level (U/ml), the ultrasound scan result (expressed as a score of 0, 1 or 3) and the menopausal status (1 if premenopausal and 3 if postmenopausal). This index was statistically virtually as effective a discriminant between cancer and benign lesions as more formal methods. Using an RMI cut-off level of 200, the sensitivity was 85% and the specificity was 97%. Patients with an RMI score of greater than 200 had, on average, 42 times the backrground risk of cancer and those with a lower value 0.15 times the background risk.