TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.
TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.
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DOI：
10.1038/ni.3248
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发表时间：
2015-10
影响因子：
30.5
通讯作者：
Bhandoola A
中科院分区：
文献类型：
--
作者：
Yang Q;Li F;Harly C;Xing S;Ye L;Xia X;Wang H;Wang X;Yu S;Zhou X;Cam M;Xue HH;Bhandoola A
驱动早期先天性淋巴细胞 (ILC) 发育的细胞和分子事件仍然知之甚少。我们证明转录因子 TCF-1 是有效生成所有已知成人 ILC 子集及其前体所必需的。使用新型报告小鼠，我们鉴定了表达大量 TCF-1 的新的早期 ILC 祖细胞 (EILP) 子集。 EILP缺乏有效的T和B淋巴细胞潜力，但有效地产生NK细胞和所有已知的成体辅助ILC谱系，表明它们是最早被识别的ILC定向祖细胞。我们的结果表明，TCF-1 表达的上调表示 ILC 命运规范的最早阶段。 EILP 的发现为破译指定 ILC 命运的其他信号提供了基础。
The cellular and molecular events that drive early innate lympoid cell (ILC) development remain poorly understood. We show that transcription factor TCF-1 is required for the efficient generation of all known adult ILC subsets and their precursors. Using novel reporter mice, we identified a new subset of early ILC progenitors (EILP) that expressed high amounts of TCF-1. EILP lacked efficient T and B lymphocyte potential, but efficiently gave rise to NK cells and all known adult helper-ILC lineages, indicating that they are the earliest identified ILC-committed progenitors. Our results suggest that upregulation of TCF-1 expression denotes the earliest stage of ILC fate specification. The discovery of EILP provides a basis to decipher additional signals that specify the ILC fate.