Application of twin screw extrusion to the manufacture of cocrystals: scale-up of AMG 517-sorbic acid cocrystal production
Application of twin screw extrusion to the manufacture of cocrystals: scale-up of AMG 517-sorbic acid cocrystal production
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DOI：
10.1039/c3fd00153a
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发表时间：
2014-01-01
影响因子：
3.4
通讯作者：
Nunez, Fernando-Alvarez
中科院分区：
文献类型：
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作者：
Daurio, Dominick;Nagapudi, Karthik;Nunez, Fernando-Alvarez
以amg517 -山梨酸为模型体系，研究了双螺杆挤出技术在共晶生产规模放大中的应用。研究了温度、进给量、螺杆转速等对共晶转化的影响。共晶的转化程度对温度有很强的依赖性，对进给量和螺杆转速有中等的依赖性。发现用TSE法制备的共晶比溶液生长的共晶具有更好的力学性能。此外，采用TSE工艺消除了对溶剂的需求。
The application of twin screw extrusion (TSE) in the scale-up of cocrystal production was investigated by using AMG 517-sorbic acid as a model system. Extrusion parameters that influenced conversion to the cocrystal such as temperature, feed rate and screw speed were investigated. Extent of conversion to the cocrystal was found to have a strong dependence on temperature and a moderate dependence on feed rate and screw speed. Cocrystals made by the TSE process were found to have superior mechanical properties than solution grown cocrystals. Additionally, moving to a TSE process eliminated the need for solvent.