A comparison of the effects of food deprivation and 2,5-anhydro-D-mannitol on metabolism and ingestion.
A comparison of the effects of food deprivation and 2,5-anhydro-D-mannitol on metabolism and ingestion.
复制标题
比较食物剥夺和 2,5-脱水-D-甘露醇对代谢和摄入的影响。
DOI：
10.1152/ajpregu.1996.270.6.r1250
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Woods,SC
中科院分区：
文献类型：
--
作者：
Park,CR;Benthem,L;Seeley,RJ;Friedman,MI;Wilkinson,CW;Woods,SC
使用呼吸商作为代谢状态的指标，我们比较了以300 mg/kg的剂量给予果糖类似物2，5-脱水-D-甘露醇（2，5-AM）的效果与10 h的食物剥夺的效果。我们测量了接受两种治疗的动物的行为和生理反应，包括食物摄入量、能量消耗、碳水化合物和脂肪酸利用率以及葡萄糖、胰岛素、皮质酮、肾上腺素和去甲肾上腺素的血浆水平。还包括溶剂处理的对照组。禁食产生的食物摄入量大于2，5-AM给药。虽然两种治疗之间的血浆葡萄糖、胰岛素和去甲肾上腺素水平相似，但接受2，5-AM的动物的血浆皮质酮和肾上腺素水平显著升高。我们的结论是，虽然2，5-AM可以产生类似于禁食的代谢状态，通过全身代谢状态指数（呼吸商）测量，但仍然存在影响食物摄入的因素，这两种情况下并不相似。
Using respiratory quotient as an index of metabolic state, we compared the effects of administrations of the fructose analogue 2,5-anhydro-D-mannitol (2,5-AM) at a dose of 300 mg/kg with the effect of 10 h of food deprivation. We measured behavioral and physiological responses of the animals receiving the two treatments, including food intake, energy expenditure, rates of carbohydrate and fatty acid utilization, and plasma levels of glucose, insulin, corticosterone, epinephrine, and norepinephrine. A vehicle-treated control group was also included. Fasting produced a greater food intake than 2,5-AM administration. Although plasma glucose, insulin, and norepinephrine levels were similar between the two treatments, plasma corticosterone and epinephrine levels were significantly elevated in animals receiving 2,5-AM. We conclude that although 2,5-AM can produce a metabolic state similar to fasting, as measured by an index of whole body metabolic state (respiratory quotient), there remain factors that influence food intake that are not similar in the two conditions.