SW-163A and B, novel immunosuppressants produced by Streptomyces sp.
SW-163A and B, novel immunosuppressants produced by Streptomyces sp.
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DOI：
10.7164/antibiotics.54.867
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发表时间：
2001-11-01
影响因子：
3.3
通讯作者：
Kurosawa, K
中科院分区：
文献类型：
--
作者：
Takahashi, K;Tsuda, E;Kurosawa, K
SW-163 A和B是从链霉菌SNA 15896发酵液中分离得到的两种新型免疫抑制剂。根据HRFAB-MS分析，SW-163 A和B的分子式分别确定为C34 H42 N2 O 12和C33 H40 N2 O 12。通过光谱分析，包括各种NMR测量，这两种化合物被阐明为大环酯结构。SW-163 A和B在体外表现出免疫抑制和抗菌活性。
SW-163A and B, novel immunosuppressants, were isolated from the culture broth of Streptomyces sp. SNA15896. The molecular formulas of SW-163A and B were determined as C34H42N2O12 and C33H40N2O12 based on the HRFAB-MS analysis, respectively. Both compounds were elucidated to be a large ring ester structure through spectroscopic analyses including various NMR measurements. SW-163A and B showed immunosuppressive and antimicrobial activities in vitro.