High environmental relative moldiness index during infancy as a predictor of asthma at 7 years of age
High environmental relative moldiness index during infancy as a predictor of asthma at 7 years of age
复制标题
DOI：
10.1016/j.anai.2011.04.018
复制
发表时间：
2011-08-01
影响因子：
5.9
通讯作者：
LeMasters, Grace
中科院分区：
文献类型：
--
作者：
Reponen, Tiina;Vesper, Stephen;LeMasters, Grace
背景资料：霉菌暴露可能有助于哮喘的发展，但以前的研究缺乏一个标准化的方法来量化exposition.Objective：以确定是否模具暴露在1和/或7岁的年龄与哮喘在7 years.Methods：本研究随访了一个高风险的出生队列从婴儿到7岁。通过基于DNA的分析，对构成1岁和7岁时环境相对发霉指数（ERMI）的36种霉菌进行了评估。在7岁时，根据症状史、肺量测定、呼出的一氧化氮和气道可逆性评估儿童的过敏性和哮喘。一份问卷调查管理的父母关于儿童的哮喘症状和其他潜在的cofactors.Results：在7岁，31 176名儿童（18%）被发现是哮喘。1岁时生活在高ERMI值（>= 5.2）家庭的儿童发生哮喘的风险是生活在低ERMI值家庭（< 5.2）的儿童的两倍多（校正比值比[aOR]，2.6; 95%置信区间[CI]，1.10-6.26）。在其他协变量中，只有父母哮喘（aOR，4.0; 95%CI，1.69-9.62）和对屋尘螨过敏（aOR，4.1; 95%CI，1.55-11.07）是哮喘发生的危险因素。相比之下，家中空调降低了哮喘发生的风险（aOR，0.3; 95%CI，0.14-0.83）。一个高ERMI值在7岁时与哮喘在7 years of age.Conclusions：早期暴露于霉菌测量ERMI在1岁，但不是7岁，显着增加了哮喘的风险在7岁。Ann Allergy Asthma Immunol.2011;107：120-126.
Background: Mold exposures may contribute to the development of asthma, but previous studies have lacked a standardized approach to quantifying exposures.Objective: To determine whether mold exposures at the ages of 1 and/or 7 years were associated with asthma at the age of 7 years.Methods: This study followed up a high-risk birth cohort from infancy to 7 years of age. Mold was assessed by a DNA-based analysis for the 36 molds that make up the Environmental Relative Moldiness Index (ERMI) at the ages of 1 and 7 years. At the age of 7 years, children were evaluated for allergic sensitization and asthma based on symptom history, spirometry, exhaled nitric oxide, and airway reversibility. A questionnaire was administered to the parent regarding the child's asthma symptoms and other potential cofactors.Results: At the age of 7 years, 31 of 176 children (18%) were found to be asthmatic. Children living in a high ERMI value (>= 5.2) home at 1 year of age had more than twice the risk of developing asthma than those in low ERMI value homes (< 5.2) (adjusted odds ratio [aOR], 2.6; 95% confidence interval [CI], 1.10-6.26). Of the other covariates, only parental asthma (aOR, 4.0; 95% CI, 1.69-9.62) and allergic sensitization to house dust mite (aOR, 4.1; 95% CI, 1.55-11.07) were risk factors for asthma development. In contrast, air-conditioning at home reduced the risk of asthma development (aOR, 0.3; 95% CI, 0.14-0.83). A high ERMI value at 7 years of age was not associated with asthma at 7 years of age.Conclusions: Early exposure to molds as measured by ERMI at 1 year of age, but not 7 years of age, significantly increased the risk for asthma at 7 years of age. Ann Allergy Asthma Immunol. 2011;107:120-126.