Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease
Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease
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DOI：
10.1016/j.neulet.2005.02.050
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发表时间：
2005-07-01
影响因子：
2.5
通讯作者：
Brown, P
中科院分区：
文献类型：
--
作者：
Fogelson, N;Kühn, AA;Brown, P
基底神经节活动在< 30 Hz频率下的过度同步是帕金森病状态的标志，并可能导致运动迟缓。因此，我们电刺激长期植入丘脑底巨电极在10帕金森氏病患者，抗帕金森病药物停药过夜后。在0、5、10、15、20、25、30、10、25、30、40、50、60、70、80 130 Hz通过测量轻敲任务中的运动时间（KT）。虽然直接刺激的影响很小，频率响应曲线显示在5-10 Hz和20-25 Hz的局部峰值，叠加在KT随刺激频率增加而降低的总体趋势上。这与这些带中的自发活动可能促进运动迟缓的假设一致。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Excessive synchronisation of basal ganglia activity at frequencies < 30 Hz is a hallmark of the parkinsonian state, and may contribute to bradykinesia. Accordingly, we electrically stimulated chronically implanted subthalamic macroelectrodes in 10 Parkin son's disease patients, after overnight withdrawal of anti-parkinsonian medication. We coin pared the effects of stimulation at 0, 5, 10, 15, 20,25, 30, and ca. 130 Hz by measuring kinesia time (KT) in a tapping task. Although the effects of direct stimulation were small, frequency-response curves demonstrated local peaks at 5-10 Hz and at 20-25 Hz, superimposed upon an overall tendency for KT to reduce with increasing stimulation frequency. This is consistent with the hypothesis that spontaneous activities in these bands might promote bradykinesia. (c) 2005 Elsevier Ireland Ltd. All rights reserved.