Proximal-type epithelioid sarcoma in pubic region expressing L-type amino acid transporter 1: A case report.
Proximal-type epithelioid sarcoma in pubic region expressing L-type amino acid transporter 1: A case report.
复制标题
DOI：
10.1177/2050313x211067917
复制
发表时间：
2022
影响因子：
0.8
通讯作者：
Hirose T
中科院分区：
文献类型：
--
作者：
Yahiro S;Fujimoto T;Fujita I;Takai T;Sakuma T;Sudo T;Morishita M;Takigami S;Kawamoto T;Hara H;Akisue T;Kuroda R;Hirose T
近端型上皮样肉瘤是一种侵袭性恶性软组织肿瘤，是上皮样肉瘤的一种“近端”变体，对多模式治疗有抵抗性，并导致早期与肿瘤相关的死亡。因此，相关治疗方法一直在不断探索中。一名24岁女性患有非转移性近端型上皮样肉瘤，起源于外阴右侧皮下，接受了手术切除；然而，病变复发，导致在第二次手术后3个月死亡。本文描述了一例表达L型氨基酸转运体1（LAT1）的近端型上皮样肉瘤病例，LAT1可转运必需氨基酸和对硼 - L - 苯丙氨酸（BPA）——硼中子俘获治疗（BNCT）中使用的化合物，且在许多恶性肿瘤中高表达。最近，LAT1引起了关注，并且相关治疗方法——LAT1抑制剂和BNCT已被研究。近端型上皮样肉瘤中LAT1的表达可能会为该疾病带来有效的治疗方法。
Proximal-type epithelioid sarcoma is an aggressive malignant soft-tissue neoplasm, a “proximal” variant of epithelioid sarcoma, resistant to multimodal therapy and involved in early tumor-related death. Pertinent treatments are, therefore, continually being explored. A 24-year-old woman with nonmetastatic proximal-type epithelioid sarcoma, originating subcutaneously on the right side of the vulva, underwent surgical resection; the lesion recurred, however, leading to death 3 months after the second surgery. Here described is a case of proximal-type epithelioid sarcoma expressing L-type amino acid transporter 1 (LAT1) that transports essential amino acids and p-borono-L-phenylalanine (BPA)—the chemical compound used in boron neutron capture therapy (BNCT)—and is highly expressed in many malignant tumors. Recently, LAT1 has drawn attention, and relevant treatments have been studied—LAT1 inhibitor and BNCT. LAT1 expression in proximal-type epithelioid sarcoma may lead to cogent treatments for the disease.