Low serum testosterone concentration in middle-aged men with type 2 diabetes
Low serum testosterone concentration in middle-aged men with type 2 diabetes
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DOI：
10.1507/endocrj.k07-077
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发表时间：
2007-12-01
影响因子：
2
通讯作者：
Nakamura, Naoto
中科院分区：
文献类型：
--
作者：
Fukui, Michiaki;Soh, Jintetsu;Nakamura, Naoto
低浓度的内源性雄激素与胰岛素抵抗和动脉粥样硬化有关。据报道，患有糖尿病的男性的血清睾酮浓度低于非糖尿病男性；然而，从来没有进行过大规模的研究。本研究的目的是调查相对较多的日本 2 型糖尿病患者的内源性雄激素浓度是否确实低于健康男性，并确定哪些因素可能与 2 型糖尿病男性血清睾酮浓度低相关。研究人员测量了 524 名健康男性和 331 名年龄在 40 至 69 岁之间患有 2 型糖尿病的连续日本男性的血清游离睾酮浓度。此外，我们还研究了血清游离睾酮浓度和黄体生成素 (LH) 浓度以及主要心血管危险因素（包括年龄、血压、血脂浓度、血糖控制 (HbA(1c)) 和 BMI）之间的关系。 2 型糖尿病男性的血清游离睾酮浓度低于 40-49 岁组的健康男性（10.9 +/- 3.3 vs. 14.0 +/- 3.6 pg/ml，P
Low concentrations of endogenous androgens have been linked with insulin resistance and atherosclerosis. Men with diabetes have been reported to have lower serum testosterone concentration than non-diabetic men; however, there has never been a large study. The aim of this study was to investigate if endogenous androgen concentration is certainly lower in a relatively large number of Japanese patients with type 2 diabetes compared with healthy men, and to identify what factors may be associated with low serum testosterone concentrations in men with type 2 diabetes. Serum free testosterone concentrations were measured in 524 healthy men and in 331 consecutive Japanese men with type 2 diabetes between 40 and 69 years old. In addition, we investigated the relationships between serum free testosterone concentration and luteinizing hormone (LH) concentration as well as major cardiovascular risk factors including age, blood pressure, plasma lipid concentration, glycemic control (HbA(1c)), and BMI. Serum free testosterone concentrations were lower in men with type 2 diabetes than in healthy men in the 40-49 years group (10.9 +/- 3.3 vs. 14.0 +/- 3.6 pg/ml, P