Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T2 characteristics of human knee articular cartilage:: topographical variation and relationships to mechanical properties
Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T2 characteristics of human knee articular cartilage:: topographical variation and relationships to mechanical properties
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DOI：
10.1002/mrm.20104
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发表时间：
2004-07-01
影响因子：
3.3
通讯作者：
Nieminen, MT
中科院分区：
文献类型：
--
作者：
Kurkijärvi, JE;Nissi, MJ;Nieminen, MT
关节软骨的大分子结构和机械性能是相互关联的，并且已知在人类膝关节中地形变化。为了研究延迟钆增强软骨MRI（dGEMRIC）、T-1和T-2标测的潜力以阐明这些差异，从非关节炎人膝关节（N = 13）的6个解剖位置制备全层软骨盘。杨氏模量和动态模量在1赫兹的测定与使用无侧限压缩测试，然后在9.4特斯拉的定量MRI测量。力学测试显示髌骨和股骨内侧/外侧髁之间的模量存在可重现的统计学显著差异。通常，股骨软骨显示出比胫骨或髌骨软骨（杨氏模量）更高的杨氏模量（>1.0 MPa）和动态模量（>8 MPa
The macromolecular structure and mechanical properties of articular cartilage are interrelated and known to vary topographically in the human knee joint. To investigate the potential of delayed gadolinium-enhanced MRI of cartilage (dGEMRIC), T-1, and T-2 mapping to elucidate these differences, full-thickness cartilage disks were prepared from six anatomical locations in nonarthritic human knee joints (N = 13). Young's modulus and the dynamic modulus at 1 Hz were determined with the use of unconfined compression tests, followed by quantitative MRI measurements at 9.4 Tesla. Mechanical tests revealed reproducible, statistically significant differences in moduli between the patella and the medial/lateral femoral condyles. Typically, femoral cartilage showed higher Young's (>1.0 MPa) and dynamic (>8 MPa) moduli than tibial or patellar cartilage (Young's modulus