Metabolic syndrome and risk factors for cardiovascular disease in obese children: the relationship with insulin resistance (HOMA-IR)
Metabolic syndrome and risk factors for cardiovascular disease in obese children: the relationship with insulin resistance (HOMA-IR)
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DOI：
10.2223/jped.1562
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发表时间：
2007-02-01
影响因子：
3.3
通讯作者：
França, Nancí Maria
中科院分区：
文献类型：
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作者：
Ferreira, Aparecido Pimentel;Oliveira, Carlos E. R.;França, Nancí Maria
目的：了解代谢综合征的患病率及心血管疾病发生的危险因素，并探讨其与胰岛素抵抗的关系。在计算了1550名学龄儿童的体重指数[体重(公斤)/身高(米)(2)]后，随机选择了样本。当儿童的BMI超过疾病控制和预防中心分类的第95个百分位数时，他们被定义为肥胖。空腹及血糖后采血检测高密度脂蛋白、甘油三酯、胰岛素。采用双能X线骨密度仪对体脂进行评价。同时测量动脉血压和胰岛素抵抗。根据国家胆固醇教育计划标准对代谢综合征进行定义，并根据调查对象的年龄调整分界点。结果：在调查的儿童中，有17.3%的儿童出现代谢综合征。胰岛素抵抗在女性(3.8+/-2.2；95%可信区间2.9-4.8)和男性(2.6+/-1.3；95%可信区间2.1-3)之间存在显著差异。1)；p=0.016。大约44.2%的样本表现出至少两个危险因素，15%的样本表现出动脉高血压。高甘油三酯血症的男女比例分别为50%和70.8%。只有女生的高密度脂蛋白水平低于理想水平。结论：肥胖儿童代谢综合征患病率高。胰岛素抵抗程度越大的儿童表现出更多的危险因素。根据这些调查结果，有必要采取干预措施，以防止儿童时期体重过度增加。
Objective: To identify the prevalence of metabolic syndrome and risk factors for the development of cardiovascular diseases and to investigate their relationship with insulin resistance.Methods: This was a cross-sectional study of 52 obese children. The sample was chosen at random after the body mass index [weight (kg)/stature (m)(2)] of 1,550 schoolchildren had been calculated. Children were defined as obese when their BMI was above the 95th percentile of the Centers for Disease Control and Prevention classification. Blood samples were taken after fasting and glycemia, high-density lipoproteins, triglycerides and insulin were all assayed. Body fat was evaluated using dual energy X-ray absorptiometry. Arterial blood pressure and insulin resistance were also measured. Metabolic syndrome was defined according to National Cholesterol Education Program criteria, with cutoff points adjusted for the age of the sample.Results: Metabolic syndrome was detected in 17.3% of the children investigated. Insulin resistance was significantly different for females (3.8 +/- 2.2; 95%CI 2.9-4.8) and males (2.6 +/- 1.3; 95%CI 2.1-3. 1); p = 0.016. Around 44.2% of the sample exhibited at least two risk factors, and 15% exhibited arterial hypertension. Hypertriglyceridemia was observed in 50 and 70.8% of boys and girls, respectively. Lower than desirable high-density lipoprotein levels were only observed among the girls.Conclusions: Obese children exhibited a high prevalence of metabolic syndrome. The children with greater insulin resistance exhibited more risk factors. In the light of these findings intervention measures are necessary in order to prevent excessive weight gain during childhood.