Reward-related brain function as a predictor of treatment response in adolescents with major depressive disorder.
Reward-related brain function as a predictor of treatment response in adolescents with major depressive disorder.
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DOI：
10.3758/cabn.10.1.107
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Dahl RE
中科院分区：
文献类型：
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作者：
Forbes EE;Olino TM;Ryan ND;Birmaher B;Axelson D;Moyles DL;Dahl RE
目前的研究提供了初步的证据表明，治疗前奖励相关的脑功能在纹状体和内侧前额叶皮层（PFC）可能有相关性预测的最终水平和变化率的临床特征的青少年抑郁症。抑郁症青少年在金钱奖励任务期间接受功能性MRI扫描，参加为期8周的认知行为疗法（CBT）或CBT加选择性5-羟色胺再摄取抑制剂的开放试验，并在治疗前、治疗期间和治疗后完成焦虑和抑郁症状的报告。临床医生在同一时间点对青少年的改善和严重程度进行评分。生长模型用于检查临床特征的变化及其与脑功能的关系。严重程度、焦虑症状和抑郁症状在治疗期间降低。严重程度和焦虑症状的最终水平与治疗前纹状体反应性相关，焦虑症状减轻率与更高的纹状体反应性和更低的内侧PFC反应性相关。
The current study provides preliminary evidence that pre-treatment reward-related brain function in the striatum and medial prefrontal cortex (PFC) could have relevance for predicting both final level and rate of change of clinical characteristics in adolescents with major depressive disorder. Adolescents with depression underwent a functional MRI scan during a monetary reward task, participated in an 8-week open trial of cognitive behavioral therapy (CBT) or CBT plus selective serotonin reuptake inhibitor, and completed reports of anxiety and depressive symptoms before, during, and after treatment. Clinicians rated adolescents' improvement and severity at the same time points. Growth models were used to examine change in clinical characteristics and its association with brain function. Severity, anxiety symptoms, and depressive symptoms decreased over treatment. Final levels of severity and anxiety symptoms were associated with pre-treatment striatal reactivity, and rate of anxiety symptom reduction was associated with greater striatal reactivity and lower medial PFC reactivity.