Ferulic Acid Reduces Cerebral Infarct Through Its Antioxidative and Anti-Inflammatory Effects Following Transient Focal Cerebral Ischemia in Rats
Ferulic Acid Reduces Cerebral Infarct Through Its Antioxidative and Anti-Inflammatory Effects Following Transient Focal Cerebral Ischemia in Rats
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DOI：
10.1142/s0192415x08006570
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发表时间：
2008-01-01
影响因子：
5.7
通讯作者：
Hsieh, Ching-Liang
中科院分区：
文献类型：
--
作者：
Cheng, Chin-Yi;Ho, Tin-Yun;Hsieh, Ching-Liang
当归和川芎在中医学中用于治疗中风已有数百年的历史。阿魏酸（FA）是AS和LC的一种成分，具有神经保护作用。本研究旨在探讨FA对脑梗死的影响及其神经保护通路的参与。大鼠大脑中动脉闭塞（MCAo）90 min后再灌注2 h和24 h。再灌注24小时后测量脑梗死和神经功能缺损。此外，在再灌注2小时和24小时后评估超氧化物自由基、细胞间粘附分子-1（ICAM-1）、髓过氧化物酶（MPO）、核因子-kappa B（NF-kappa B）免疫反应细胞的表达。在MCAo开始时给予80和100 mg/kg FA可显著降低脑梗死和神经功能缺损评分，在MCAo后30 min给予100 mg/kg FA可获得类似的结果。FA处理（100 mg/kg i. v.）有效地抑制了脑实质损伤中的超氧自由基和缺血纹状体中的ICAM-1免疫反应血管
Both Angelica sinensis (Oliv) Diels (AS) and Ligusticum chuanxiong Hort. (LC) have been used to treat stroke in traditional Chinese medicine for centuries. Ferulic acid (FA), a component in both AS and LC, plays a role in neuroprotection. The purpose of this study was to investigate the effects of FA on cerebral infarct and the involvement of neuroprotective pathway. Rats underwent 2 hours and 24 hours of reperfusion after 90min middle cerebral artery occlusion (MCAo). The cerebral infarct and neurological deficits were measured after 24 hours of reperfusion. Furthermore, the expression of superoxide radicals, intercellular adhesion molecule-1 (ICAM-1), myeloperoxidase (MPO), nuclear factor-kappa B (NF-kappa B) immunoreactive cells were assessed after 2 hours and 24 hours of reperfusion. Administration of 80 and 100 mg/kg of FA at the beginning of MCAo significantly reduced cerebral infarct and neurological deficit-score, similar results were obtained by 100 mg/kg of FA administered 30min after MCAo. FA treatment (100 mg/kg i.v.) effectively suppressed superoxide radicals in the parenchyma lesion, and ICAM-1 immunoreactive vessels in the ischemic striatum