Interindividual differences in the dynamics of the homeostatic process are trait‐like and distinct for sleep versus wakefulness
Interindividual differences in the dynamics of the homeostatic process are trait‐like and distinct for sleep versus wakefulness
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DOI：
10.1111/jsr.12483
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发表时间：
2017-04
影响因子：
4.4
通讯作者：
T. Rusterholz;L. Tarokh;H. V. Van Dongen;P. Achermann
中科院分区：
文献类型：
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作者：
T. Rusterholz;L. Tarokh;H. V. Van Dongen;P. Achermann
睡眠稳态过程 S 反映了清醒时睡眠压力的积累和睡眠期间睡眠压力的消散。过程 S 被建模为清醒期间的饱和指数函数和睡眠期间的递减指数函数。慢波活动是非快速眼动 (non-REM) 睡眠强度的生理标志，可作为过程 S 的指标。对睡眠和睡眠剥夺的睡眠稳态反应存在相当大的个体差异。本研究的目的是调查 Process S 中的个体差异是否具有特质特征。对 11 名健康年轻人进行了 8 晚（12 小时睡眠机会，22:00–10:00）的多导睡眠图记录，其中穿插着三个 36 小时的持续清醒期。每次非快速眼动睡眠发作中点的经验平均慢波活动用于参数估计。使用连续睡眠记录的不同组合来估计过程 S 的参数，从而为每个受试者提供两到三组参数。计算组内相关系数以评估参数在整个研究方案中是否稳定，并且它们显示出个体之间的性状变异性。我们发现过程 S 的建立和消散的组平均时间常数分别为 19.2 和 2.7 小时。组内相关系数范围为 0.48 至 0.56，反映了中等的性状变异性。建立和消散的时间常数在受试者之间独立变化，表明两个不同的特征。我们得出的结论是，睡眠稳态过程 S 的动态参数的个体间差异是特征状的。
The sleep homeostatic Process S reflects the build‐up of sleep pressure during waking and its dissipation during sleep. Process S is modelled as a saturating exponential function during waking and a decreasing exponential function during sleep. Slow wave activity is a physiological marker for non‐rapid eye movement (non‐REM) sleep intensity and serves as an index of Process S. There is considerable interindividual variability in the sleep homeostatic responses to sleep and sleep deprivation. The aim of this study was to investigate whether interindividual differences in Process S are trait‐like. Polysomnographic recordings of 8 nights (12‐h sleep opportunities, 22:00–10:00 hours) interspersed with three 36‐h periods of sustained wakefulness were performed in 11 healthy young adults. Empirical mean slow wave activity per non‐REM sleep episode at episode mid‐points were used for parameter estimation. Parameters of Process S were estimated using different combinations of consecutive sleep recordings, resulting in two to three sets of parameters per subject. Intraclass correlation coefficients were calculated to assess whether the parameters were stable across the study protocol and they showed trait‐like variability among individuals. We found that the group‐average time constants of the build‐up and dissipation of Process S were 19.2 and 2.7 h, respectively. Intraclass correlation coefficients ranged from 0.48 to 0.56, which reflects moderate trait variability. The time constants of the build‐up and dissipation varied independently among subjects, indicating two distinct traits. We conclude that interindividual differences in the parameters of the dynamics of the sleep homeostatic Process S are trait‐like.