The LRR and Ig domain-containing membrane protein SST273 is expressed on motoneurons
The LRR and Ig domain-containing membrane protein SST273 is expressed on motoneurons
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DOI：
10.1016/j.modgep.2005.08.005
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发表时间：
2006-03-01
影响因子：
1.2
通讯作者：
Tanaka, H
中科院分区：
文献类型：
--
作者：
Gejima, R;Okafuji, T;Tanaka, H
我们利用鸡胚胎脊髓运动神经元的cDNA文库进行了信号序列陷阱克隆，并鉴定出一个新的跨膜分子SST273(信号序列陷阱克隆273)。SST273的胞外区有5个富含亮氨酸重复序列(LRR)和1个免疫球蛋白(Ig)结构域。SST273的人(KIAA1465)和小鼠(BC059068)同源基因已被克隆，但尚未进行分析。鸡SST273与人和小鼠同源基因的氨基酸同源性分别为52.1%和51.5%。SST273mRNA及其蛋白产物在胚胎发育早期的脊髓运动神经元和颅运动神经元中有独特的表达。(C)2005 Elsevier B.V.保留所有权利。
We performed signal sequence trap cDNA cloning using a cDNA library of enriched chicken embryonic spinal motoneurons and identified a novel transmembrane molecule, SST273 (Signal Sequence Trap clone 273). SST273 has five leucine-rich repeats (LRRs) and one immumoglobulin (Ig) domain in its extracellular domain. The human (KIAA1465) and mouse (BC059068) homologues of SST273 were already cloned, but had not yet been analyzed. The amino acid homologies between chick SST273 and human or mouse homologue are 52.1 and 51.5%, respectively. SST273 mRNA and its protein product were uniquely expressed in the embryonic spinal and cranial motoneurons at early developmental stages. (C) 2005 Elsevier B.V. All rights reserved.