A 3-month home use study comparing the oral hygiene and gingival health benefits of triclosan and conventional fluoride toothpastes.
A 3-month home use study comparing the oral hygiene and gingival health benefits of triclosan and conventional fluoride toothpastes.
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一项为期 3 个月的家庭使用研究，比较了三氯生和传统含氟牙膏的口腔卫生和牙龈健康益处。
DOI：
10.1111/j.1600-051x.1996.tb00531.x
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发表时间：
1996
影响因子：
6.7
通讯作者：
L. Everatt
中科院分区：
文献类型：
--
作者：
A. Binney;M. Addy;J. Owens;J. Faulkner;S. McKeown;L. Everatt
与不含三氯生的对照配方相比，许多三氯生牙膏已被证明有利于牙龈健康。很少有研究将这些活性产品与传统的含氟牙膏产品进行比较。本研究的目的是比较，在家庭使用中，三氯生产品与传统的氟化物产品已经发现，在短期菌斑再生研究中显示出略低的菌斑抑制。这项研究是一项单盲、平行设计，共有129名健康的牙齿志愿者（32名男性，97名女性）在家中用4种牙膏产品中的一种刷牙，每天两次，为期12周。在试验开始时，对每位志愿者进行牙菌斑和牙龈炎评分，然后接受全面预防。根据预先确定的随机化方案，为每位志愿者分配牙膏。志愿者在6周和12周后重新检查。志愿者在试验期间避免使用任何其他口腔卫生产品。测试的牙膏是两种传统氟化物牙膏、一种儿童氟化物牙膏和一种三氯生/共聚物牙膏。结果表明，无论是菌斑指数还是牙龈指数，总体上都没有显着的治疗差异，牙膏的订购是不可能的。所有志愿者的口腔卫生和牙龈炎在6周后得到改善，并持续改善到第12周。这是大多数口腔卫生试验的一个特征，可能是由于受试者最初的预防和对改善牙齿清洁的霍桑反应。从本研究中可以得出结论，在正常的家庭使用中，三氯生/共聚物牙膏提供的口腔卫生和牙龈健康益处不超过传统牙膏产品。
A number of triclosan toothpastes are available which have been shown to benefit gingival health when compared to triclosan free control formulations. There have been few studies to compare such active products with conventional fluoride toothpaste products. The aim of this study was to compare, in home use, a triclosan product with conventional fluoride products already found to show slightly less plaque inhibition in a short term plaque regrowth study. The study was a single-blind, parallel design with a total of 129 healthy dentate volunteers (32 male, 97 female) who toothbrushed with one of 4 toothpaste products at home, twice a day over a period of 12 weeks. At the beginning of the trial, each volunteer was scored for plaque and gingivitis and then received a through prophylaxis. Each volunteer was allocated a toothpaste according to a predetermined randomisation scheme. The volunteers were re-examined after 6 and 12 weeks. The volunteers refrained from using any other oral hygiene products during the period of the trial. The toothpastes tested were two conventional fluoride toothpastes, a children's fluoride toothpaste and a triclosan/copolymer toothpaste. Results indicated that there were no overall significant treatment differences for either plaque index or gingival index and ordering of toothpastes was not possible. All volunteers' oral hygiene and gingivitis improved following the 6-week period and continued to improve to the 12th week. This is a feature of most oral hygiene trials and presumably arises from the initial prophylaxis and a Hawthorne response of improved toothcleaning by the subjects. It must be concluded from this study that in normal home use the triclosan/copolymer toothpaste provides oral hygiene and gingival health benefits no greater than achievable with conventional toothpaste products.