Transition-Metal-Free N-O Reduction of Oximes: A Modular Synthesis of Fluorinated Pyridines
Transition-Metal-Free N-O Reduction of Oximes: A Modular Synthesis of Fluorinated Pyridines
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肟的无过渡金属 N-O 还原：氟化吡啶的模块化合成
DOI：
10.1021/acs.orglett.7b01564
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发表时间：
2017-07-21
期刊：
影响因子：
5.2
通讯作者：
Deng, Guo-Jun
中科院分区：
文献类型：
--
作者：
Huang, Huawen;Cai, Jinhui;Deng, Guo-Jun
已经探索了基于NH 4 I的还原系统以促进肟N-O键断裂，从而使得能够模块化合成宽范围的具有重要意义的氟化吡啶。与传统的吡啶组装方法相比，该方法具有高度的区域选择性和化学选择性，并具有广泛的官能团耐受性。
An NH4I-based reductive system has been explored to promote :the oxime N-O bond cleavage and thereby enable a Modular synthesis of a broad range, of pharmacologically significant fluorinated pyridines. Compared With traditional condensation methods for pyridine assembly, this protocol was found to be highly regio- and chemoselective and presented broad functional group tolerance.