g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)
g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)
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DOI：
10.1093/nar/gkz369
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发表时间：
2019-07-02
影响因子：
14.9
通讯作者：
Vilo, Jaak
中科院分区：
文献类型：
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作者：
Raudvere, Uku;Kolberg, Liis;Vilo, Jaak
生物学数据分析通常处理来自各种研究的基因列表。Profiler工具集广泛用于查找基因列表中丰富的生物类别，基因标识符之间的转换以及到其同源物的映射。g:Profiler的使命是提供可靠的服务，基于最新的高质量数据，以方便的方式跨许多证据类型，标识符空间和生物体。g:Profiler依赖于Ensembl作为主要数据源，并遵循他们的季度发布周期，同时更新其他数据源。当前的更新提供了一个更好的用户体验，由于一个现代的响应式web界面，标准化的API和库。结果通过交互式和可配置的网页设计交付。结果可以下载为可供发布的可视化文件或带分隔符的文本文件。在当前的更新中，我们已经扩展了对467种物种和菌株的支持，包括脊椎动物、植物、真菌、昆虫和寄生虫。通过支持用户上传自定义GMT文件，g:Profiler现在能够分析来自任何生物体的数据。所有过去的版本都保持可重复性和透明度。2019年的更新引入了广泛的技术重写，使服务更快、更灵活。g:Profiler可在https://biit.cs.ut.ee/gprofiler免费获得。
Biological data analysis often deals with lists of genes arising from various studies. The g:Profiler toolset is widely used for finding biological categories enriched in gene lists, conversions between gene identifiers and mappings to their orthologs. The mission of g:Profiler is to provide a reliable service based on up-to-date high quality data in a convenient manner across many evidence types, identifier spaces and organisms. g:Profiler relies on Ensembl as a primary data source and follows their quarterly release cycle while updating the other data sources simultaneously. The current update provides a better user experience due to a modern responsive web interface, standardised API and libraries. The results are delivered through an interactive and configurable web design. Results can be downloaded as publication ready visualisations or delimited text files. In the current update we have extended the support to 467 species and strains, including vertebrates, plants, fungi, insects and parasites. By supporting user uploaded custom GMT files, g:Profiler is now capable of analysing data from any organism. All past releases aremaintained for reproducibility and transparency. The 2019 update introduces an extensive technical rewrite making the services faster and more flexible. g:Profiler is freely available at https://biit.cs.ut.ee/gprofiler.