Lack of evidence for an association between α-adducin and blood pressure regulation in Asian populations
Lack of evidence for an association between α-adducin and blood pressure regulation in Asian populations
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DOI：
10.1016/s0895-7061(00)00238-7
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发表时间：
2000-06-01
影响因子：
3.2
通讯作者：
Risch, N
中科院分区：
文献类型：
--
作者：
Ranade, K;Hsuing, AC;Risch, N
最近的研究发现，α -内收蛋白460位（G460W）的甘氨酸-色氨酸多态性色氨酸等位基因与欧洲人群的原发性高血压有关。我们研究了色氨酸等位基因是否与不同人群的高血压有关，这些人群包括来自台湾的中国血统，以及来自旧金山湾区和夏威夷的中国和日本血统。我们采用5′等位基因区分法或TaqMan对个体进行G460W多态性分型，并使用该方法对1000多个个体进行分型。中国人群中W等位基因的频率略有增加（0.458 v 0.323），而日本人群中W等位基因的频率没有增加（0.549 v 0.558）。我们在分析中考虑了显性、隐性和可加性模型。中国人群收缩压的隐性模型有显著结果（chi(2) 6.84, df = 2, P < 0.05），但舒张压只有暗暗性证据（chi(2) 3.30）。相比之下，在日本人口中，没有证据表明在任何模型下都存在正相关。对于中国和日本的联合样本，与α -内收蛋白相关的证据并不显著。Am J Hypertens 2000；[j]中华高血压病杂志，2000。
Recent studies have found the tryptophan allele of a glycine to tryptophan polymorphism at position 460 (G460W) of the alpha-adducin protein to be associated with essential hypertension in European populations. We examined whether the tryptophan allele is associated with hypertension in a different population, comprised of subjects of Chinese origin from Taiwan, and Chinese and Japanese origin from the San Francisco Bay area and Hawaii. We adapted the 5' allelic discrimination assay or TaqMan to type individuals for the G460W polymorphism, and using this method we typed more than 1000 individuals. The frequency of the W allele was slightly increased in the treated subjects in the Chinese population (0.458 v 0.323) but not the Japanese population (0.549 v 0.558). We considered dominant, recessive, and additive models in our analysis. There was a significant result for a recessive model for systolic blood pressure in the Chinese population (chi(2) 6.84, df = 2, P < .05), but only suggestive evidence for diastolic blood pressure (chi(2) 3.30). In contrast, in the Japanese population, there was no evidence for a positive association under any model. For the combined Chinese and Japanese samples, the evidence for association with alpha-adducin was not significant. Am J Hypertens 2000;13:704-709 (C) 2000 American Journal of Hypertension, Ltd.