The association between childhood depression and adulthood body mass index
The association between childhood depression and adulthood body mass index
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DOI：
10.1542/peds.107.5.1049
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发表时间：
2001-05-01
期刊：
影响因子：
8
通讯作者：
Weissman, MM
中科院分区：
文献类型：
--
作者：
Pine, DS;Goldstein, RB;Weissman, MM
Objective.童年时期的压力与童年抑郁和成年体重指数（BMI）升高有关，BMI是相对超重的衡量标准。然而，关于儿童期重度抑郁症与成年期BMI之间的关联的数据有限。目前的研究探讨这种关联。在哥伦比亚长老会医疗中心确定了患有重度抑郁症（n = 90）或无精神障碍（n = 87）的6至17岁儿童，并在10至15年后进行了随访。通过标准化的精神病学访谈评估入院和随访时的精神状态。记录成年期的BMI，以便随着时间的推移可以考虑抑郁症和BMI之间的联系。儿童期抑郁症患者成年后的BMI为26.1 +/- 5.2，而健康对照组的BMI为24.2 +/- 4.1（t（175）= 2.7）。这种关联不能用一些潜在的混杂因素来解释，包括年龄、性别、吸烟或饮酒、社会阶层、怀孕或用药史。虽然成年期的贫困也可以预测成年后的BMI，但在多变量模型中，贫困与成年后的BMI（t（152）= 2.9）以及儿童期抑郁与成年后的BMI（t（152）= 2.2）之间的相关性都是显著的。最后，童年和成年之间的抑郁持续时间也成为成人BMI的预测因子。儿童期的抑郁症与成年期的BMI呈正相关。这种关联不能用各种潜在的混杂变量来解释，可能会随着儿童进入成年而发展。
Objective. Stress in childhood relates to both childhood depression and elevated adult body mass index (BMI), a measure of relative overweight. However, there are limited data on the association between major depression in childhood and BMI in adulthood. The current study examines this association.Method. Children 6 to 17 years old with major depression (n = 90) or no psychiatric disorder (n = 87) were identified at Columbia Presbyterian Medical Center and followed up 10 to 15 years later. Psychiatric status at intake and follow-up was assessed via standardized psychiatric interviews. BMI during adulthood was recorded so that the association between depression and BMI could be considered over time.Results. Participants with childhood major depression had a BMI of 26.1 +/- 5.2 as adults, compared with a BMI of 24.2 +/- 4.1 in healthy comparisons (t(175) = 2.7). This association could not be explained by a number of potentially confounding factors, including age, gender, cigarette or alcohol use, social class, and pregnancy or medication history. Although poverty during adulthood also predicted adult BMI, both the association between poverty and adult BMI (t(152) = 2.9), as well as between childhood depression and adult BMI (t(152) = 2.2) were significant in a multivariate model. Finally, duration of depression between childhood and adulthood also emerged as a predictor of adult BMI.Conclusions. Depression during childhood is positively associated with BMI during adulthood. This association cannot be explained by various potential confounding variables and may develop over time as children pass into their adult years.