Nanometer-Scale Structures of Neurons Differ Between Individuals and Those Differences Become Extraordinary in Schizophrenia
Nanometer-Scale Structures of Neurons Differ Between Individuals and Those Differences Become Extraordinary in Schizophrenia
复制标题
神经元的纳米级结构因人而异，这些差异在精神分裂症中变得非凡
DOI：
10.1017/s1431927619007451
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发表时间：
2019
影响因子：
2.8
通讯作者：
RMizutani
中科院分区：
文献类型：
--
作者：
Rino Saiga(筆頭者) Vincent De Andrade Francesco De Carlo Akihisa Takeuchi Kentaro Uesugi Y Terada;Y Suzuki;S Takekoshi;C Inomoto;N Nakamura;Y Torii;I Kushima;S Iritani;N Ozaki;K Oshima;M Itokawa;M Arai;RMizutani
大脑由大量神经元组成，形成微米到纳米级的网络。本研究报告了用同步辐射纳米断层扫描技术对精神分裂症患者和对照组的脑神经元进行三维分析。结果表明，不同个体的神经元结构不同，这些差异在精神分裂症患者中变得非同寻常。我们认为神经元的这种结构差异反映了人类的心理个性[1]。本研究中使用的脑组织取自前扣带回皮质。据报道，这一大脑区域负责较高的大脑功能，包括决策，并与精神分裂症和自闭症等精神疾病有关。脑组织进行高尔基染色，以便在X射线图像中显示神经元[2]。将染色的组织包埋在环氧树脂中，进行纳米层析成像。这项研究是按照相关组织伦理委员会批准的程序进行的。
The brain consists of a huge number of neurons forming micrometer-to nanometer-scale networks. This study reports a three-dimensional analysis of brain neurons of schizophrenia sufferers and control cases using synchrotron radiation nanotomography. The results indicate that neuronal structures differ between individuals, and those differences become extraordinary in schizophrenia. We suggest that such structural differences in neurons reflect the mental individuality of humans [1].The cerebral tissues used in this study were taken from the anterior cingulate cortex. It has been reported that this brain area is responsible for higher brain functions, including decision-making and is related to psychiatric diseases, such as schizophrenia and autism. The brain tissues were impregnated with Golgi staining in order to visualize the neurons in x-ray images [2]. The stained tissues were embedded in epoxy resin and subjected to nanotomography. The study was conducted according to the procedure approved by the ethics committees of the related organizations.