THE CLONING OF A FAMILY OF GENES THAT ENCODE THE MELANOCORTIN RECEPTORS
THE CLONING OF A FAMILY OF GENES THAT ENCODE THE MELANOCORTIN RECEPTORS
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DOI：
10.1126/science.1325670
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发表时间：
1992-08-28
期刊：
影响因子：
56.9
通讯作者：
CONE, RD
中科院分区：
文献类型：
--
作者：
MOUNTJOY, KG;ROBBINS, LS;CONE, RD
促黑素细胞激素（MSH）和促肾上腺皮质激素（ACTH）分别调节色素沉着和肾上腺皮质功能。这些肽在其他领域也具有多种生物活性，包括大脑，垂体和免疫系统。要完全了解这些激素的生物活性，需要分离和表征其相应的受体。克隆了鼠和人MSH受体（MSH-Rs）和人ACTH受体（ACTH-R）。这些受体定义了与鸟嘌呤核苷酸结合蛋白偶联的受体亚家族，其可能包括大麻素受体。
Melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) regulate pigmentation and adrenal cortical function, respectively. These peptides also have a variety of biological activities in other areas, including the brain, the pituitary, and the immune system. A complete understanding of the biological activities of these hormones requires the isolation and characterization of their corresponding receptors. The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned. These receptors define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor.