Correlation between tuberous sclerosis complex 2 and glycogen synthase kinase 3 beta levels, and outcomes of patients with hepatocellular carcinoma treated by hepatectomy
Correlation between tuberous sclerosis complex 2 and glycogen synthase kinase 3 beta levels, and outcomes of patients with hepatocellular carcinoma treated by hepatectomy
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DOI：
10.1111/hepr.12256
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发表时间：
2014-10-01
影响因子：
4.2
通讯作者：
Shan, Yun-Feng
中科院分区：
文献类型：
--
作者：
Huang, Ka-Te;Huang, Yue-Han;Shan, Yun-Feng
目的性硬化复合物2（TSC 2）是一种肿瘤抑制因子，可能在能量应激条件下调节细胞生长和细胞存活方面发挥重要作用。此外，TSC2可以通过糖原合成酶激酶3（GSK 3）的额外磷酸化与Wnt和能量信号协同作用以调节细胞生长。方法采用免疫组化SP法检测20例正常肝组织、80例肝癌组织及80例癌旁组织中TSC 2和GSK 3的表达。结果HCC组织中TSC 2和GSK 3蛋白表达水平明显低于正常肝组织和癌旁组织（P
AimTuberous sclerosis complex 2 (TSC2), a tumor suppressor, may play an essential role in the regulation of cell growth and cell survival under energy stress conditions. In addition, TSC2 may act in concert with Wnt and energy signals by additional phosphorylation of glycogen synthase kinase 3 (GSK3) to regulate cell growth. The expression levels and function of TSC2 and GSK3 in hepatocellular carcinoma (HCC) remain unclear.MethodsThe protein levels of TSC2 and GSK3 were measured by immunohistochemistry in normal liver (n=20), HCC (n=80) and pericancerous tissues (n=80). The correlations between TSC2, and GSK3 levels, clinicopathological features and patient survival were also analyzed.ResultsThe protein levels of TSC2 and GSK3 in HCC tissues were significantly lower than that in normal liver tissues and pericancerous tissues (P