Migraine in postmenopausal women and the risk of invasive breast cancer.
Migraine in postmenopausal women and the risk of invasive breast cancer.
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绝经后妇女的偏头痛和侵入性乳腺癌的风险。
DOI：
10.1158/1055-9965.epi-08-0527
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发表时间：
2008-11
期刊：
影响因子：
--
通讯作者：
Li CI
中科院分区：
文献类型：
--
作者：
Mathes RW;Malone KE;Daling JR;Davis S;Lucas SM;Porter PL;Li CI
偏头痛的频率在女性生殖周期的不同时期有所不同。月经初潮、月经、怀孕和围绝经期可能带有不同的偏头痛风险，这可能是因为雌激素水平的波动，而且总的来说，偏头痛的频率与雌激素水平的下降有关。鉴于内源性雌激素水平与乳腺癌风险之间的密切关系，偏头痛患者患乳腺癌的风险可能会降低。我们结合了两项基于人群的病例对照研究的数据，在1,199名导管癌患者、739名小叶癌患者和1,474名年龄在55-79岁的对照组中，研究了偏头痛与绝经后浸润性乳腺癌风险的关系。多因素Logistic回归用于估计优势比和95%可信区间；所有统计检验均为双侧。报告临床诊断为偏头痛的女性患导管癌(IDC)[优势比(OR)：0.67，95%可信区间(CI)：0.54-0.82]和小叶癌(ILC)(OR：0.68，95%CI：0.52-0.90)的风险降低。这些关联主要限于激素受体阳性的肿瘤，因为偏头痛与雌激素受体(ER)阳性/孕激素受体(PR)阳性导管癌的风险降低0.65倍(95%CI：0.51-0.83)有关。观察到的风险降低出现在使用和不使用处方药治疗偏头痛的偏头痛患者中。这些数据表明，偏头痛病史与乳腺癌风险的降低有关，特别是在ER+/PR+导管和小叶癌中。因为这是第一个解决偏头痛病史和乳腺癌风险之间关系的研究，所以需要更多的研究来证实这一发现。
The frequency of migraine headache changes at various times of a woman's reproductive cycle. Menarche, menses, pregnancy, and perimenopause may carry a different migraine risk conceivably because of fluctuating estrogen levels, and in general migraine frequency is associated with falling estrogen levels. Given the strong relationship between endogenous estrogen levels and breast cancer risk, migraine sufferers may experience a reduced risk of breast cancer. We combined data from two population-based case-control studies to examine the relationship between migraine and risk of postmenopausal invasive breast cancer among 1,199 ductal carcinoma cases, 739 lobular carcinoma cases, and 1,474 controls 55-79 years of age. Polytomous logistic regression was used to estimate odds ratios and 95% confidence intervals; all statistical tests were 2-sided. Women who reported a clinical diagnosis of migraine had reduced risks of ductal carcinoma (IDC) [odds ratio (OR): 0.67, 95% confidence interval (CI): 0.54-0.82] and lobular carcinoma (ILC) (OR: 0.68, 95% CI: 0.52-0.90). These associations were primarily limited to hormone receptor positive tumors as migraine was associated with a 0.65-fold (95% CI: 0.51-0.83) reduced risk of estrogen receptor (ER) positive/progesterone receptor (PR) positive ductal carcinoma. The reductions in risk observed were seen among migraine sufferers who did and did not use prescription medications for their migraines. These data suggest a history of migraine is associated with a decreased risk of breast cancer, particularly among ER+/PR+ ductal and lobular carcinomas. Because this is the first study to address an association between migraine history and breast cancer risk, additional studies are needed to confirm this finding.