Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease
Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease
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DOI：
10.1164/rccm.200310-1404oc
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发表时间：
2004-10-15
影响因子：
24.7
通讯作者：
Kimura, H
中科院分区：
文献类型：
--
作者：
Itoh, T;Nagaya, N;Kimura, H
胃饥饿素是一种新型生长激素释放肽，已被证明可以通过减少脂肪消耗和刺激食物摄入来实现正能量平衡。本研究调查了血浆生长素释放肽是否与慢性阻塞性肺疾病患者的临床参数相关。测量了 50 名患者和 13 名对照受试者的血浆生长素释放肽，以及合成代谢和分解代谢因子。根据体重指数将患者分为两组：体重不足的患者（n = 26）或体重正常的患者（n = 24）。体重不足的患者血浆生长素释放肽显着高于体重正常的患者和健康对照受试者。体重不足患者的循环肿瘤坏死因子-α、白介素-6 和去甲肾上腺素显着高于正常体重患者。血浆生长素释放肽与体重指数呈负相关，与肿瘤坏死因子-α和去甲肾上腺素等分解代谢因子呈正相关。此外，血浆生长素释放肽与预测残气量百分比和残气量与总肺容量的比率呈正相关。总之，体重过轻的慢性阻塞性肺病患者血浆生长素释放肽升高，且该水平与恶病质状态和肺功能异常相关。
Ghrelin, a novel growth hormone-releasing peptide, has been shown to cause a positive energy balance by reducing fat use and stimulating food intake. This study investigated whether plasma ghrelin is associated with clinical parameters in patients with chronic obstructive pulmonary disease. Plasma ghrelin was measured in 50 patients and 13 control subjects, together with anabolic and catabolic factors. Patients were divided into two groups based on body mass index: underweight patients (n = 26) or normal weight patients (n = 24). Plasma ghrelin was significantly higher in underweight patients than in normal weight patients and healthy control subjects. Circulating tumor necrosis factor-alpha, interleukin-6, and norepinephrine were significantly higher in underweight patients than in normal weight patients. Plasma ghrelin correlated negatively with body mass index and correlated positively with catabolic factors such as tumor necrosis factor-alpha and norepinephrine. In addition, plasma ghrelin correlated positively with percent predicted residual volume and residual volume-to-total lung capacity ratio. In conclusion, plasma ghrelin was elevated in underweight patients with chronic obstructive pulmonary disease, and the level was associated with a cachectic state and abnormality of pulmonary function.