TYROSINASE INHIBITORS FROM CRUDE DRUGS
TYROSINASE INHIBITORS FROM CRUDE DRUGS
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DOI：
10.1248/bpb.17.266
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发表时间：
1994-02-01
影响因子：
2
通讯作者：
YOKOKURA, T
中科院分区：
文献类型：
--
作者：
SHIROTA, S;MIYAZAKI, K;YOKOKURA, T
对各种生药的酪氨酸酶抑制活性进行了检测。Chouji和Yakuchi提取物具有明显的活性，活性物质经鉴定分别为丁香酚和雅库西酮A。其他香草基化合物如阿魏酸、姜黄素和雅库希酮B的活性也高于丁香酚和雅库希酮A，对酶有竞争性抑制作用。这些物质中肉桂酰基芳环的4位羟基和与芳环共轭的α，β-不饱和羰基的存在可能在酪氨酸酶的竞争抑制中起重要作用。
Various crude drugs were examined for their tyrosinase inhibitory activity. Marked activity was observed in Chouji and Yakuchi extracts and the active substances in these extracts were identified as eugenol and yakuchinone A, respectively. Other vanillyl compounds such as ferulic acid, curcumin and yakuchinone B also had higher activities than eugenol or yakuchinone A and inhibited the enzyme competitively. The presence of the hydroxyl group at the 4 position of the aromatic ring of the cinnamoyl moiety and the alpha,beta-unsaturated carbonyl conjugated with an aromatic ring in these substances may play important roles in the competitive inhibition of tyrosinase.