25-Hydroxyvitamin D Levels and Risk of Ischemic Heart Disease, Myocardial Infarction, and Early Death Population-Based Study and Meta-Analyses of 18 and 17 Studies
25-Hydroxyvitamin D Levels and Risk of Ischemic Heart Disease, Myocardial Infarction, and Early Death Population-Based Study and Meta-Analyses of 18 and 17 Studies
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DOI：
10.1161/atvbaha.112.248039
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发表时间：
2012-11-01
影响因子：
8.7
通讯作者：
Nordestgaard, Borge G.
中科院分区：
文献类型：
--
作者：
Brondum-Jacobsen, Peter;Benn, Marianne;Nordestgaard, Borge G.
我们测试的假设，减少血浆25-羟基维生素D与缺血性心脏病，心肌梗死，和早期death.Methods和结果的风险增加，我们测量基线血浆25-羟基维生素D在10 170名妇女和男子从丹麦一般人群没有维生素D强化食品。在29年的随访中，3100人发生缺血性心脏病，1625人心肌梗死，6747人死亡。血浆25-羟基维生素D水平降低与缺血性心脏病、心肌梗死和早期死亡风险增加相关，作为季节性调整百分位数分类的函数（趋势P，2x 10（-4）-3x10（-53））。将血浆25-羟基维生素D水平在第1至第4百分位数的个体与水平在第50至第100百分位数的个体进行比较，多变量校正风险增加40%。（95% CI，14%-72%）缺血性心脏病，64%（25%-114%），早期死亡57%（38%-78%），致死性缺血性心脏病/心肌梗死81%（40%-135%）。在18和17项研究的荟萃分析中，缺血性心脏病和早期死亡的风险分别增加了39%（25%-54%）和46%（31%-64%）的最低与最高四分位数的25-hydroxyvitamin D level. Conclusion，我们观察到缺血性心脏病，心肌梗死和早期死亡的风险增加与血浆25-hydroxyvitamin D水平下降。这些发现在荟萃分析中得到证实。（Arterioscler Thromb Vasc Biol.2012;32：2794-2802.）
Objective-We tested the hypothesis that reduced plasma 25-hydroxyvitamin D associates with increased risk of ischemic heart disease, myocardial infarction, and early death.Methods and Results-We measured baseline plasma 25-hydroxyvitamin D in 10 170 women and men from the Danish general population without vitamin D-fortified food. During 29 years of follow-up, 3100 persons developed ischemic heart disease, 1625 myocardial infarction, and 6747 died. Decreasing plasma 25-hydroxyvitamin D levels were associated with increasing risk of ischemic heart disease, myocardial infarction, and early death as a function of seasonally adjusted percentile categories (P for trend, 2x10(-4)-3x10(-53)). Comparing individuals with plasma 25-hydroxyvitamin D levels at the 1st to 4th percentile with individuals with levels at the 50th to 100th percentile, the multivariable adjusted risk was increased by 40% (95% CI, 14%-72%) for ischemic heart disease, by 64% (25%-114%) for myocardial infarction, by 57% (38%-78%) for early death, and by 81% (40%-135%) for fatal ischemic heart disease/myocardial infarction. In the meta-analyses of 18 and 17 studies, risk of ischemic heart disease and early death were increased by 39% (25%-54%) and 46% (31%-64%) for lowest versus highest quartile of 25-hydroxyvitamin D level.Conclusion-We observed increasing risk of ischemic heart disease, myocardial infarction, and early death with decreasing plasma 25-hydroxyvitamin D levels. These findings were substantiated in meta-analyses. (Arterioscler Thromb Vasc Biol. 2012;32:2794-2802.)