Contribution of smoking, disease history, and survival to lung cancer disparities in Black individuals.
Contribution of smoking, disease history, and survival to lung cancer disparities in Black individuals.
复制标题
吸烟、疾病史和生存率对黑人肺癌差异的影响。
DOI：
10.1093/jncimonographs/lgad016
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Meza,Rafael
中科院分区：
文献类型：
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作者：
Skolnick,Sarah;Cao,Pianpian;Jeon,Jihyoun;Meza,Rafael
背景肺癌是癌症死亡的主要原因，并且不成比例地影响自我认定的黑人或非裔美国人（“黑人”），特别是考虑到他们自我报告的相对较低的吸烟强度率。本研究旨在确定吸烟史和肺癌发病风险，组织学，阶段和生存对这些differences.MethodsWe使用了2肺癌模型（EuganLung，所有种族和EuganLung，黑色），以了解为什么黑人有较高的肺癌死亡率的相对影响。我们研究了如何不同的因素，如吸烟行为，癌症的发展，组织学，诊断阶段，和肺癌的生存，有助于这些differentiation.ResultsAdjusted吸烟史，大约90%的差异，肺癌死亡之间的整体和黑人人口（出生于1960年）是在肺癌的风险差异的结果。肺癌的组织学和分期以及生存率的差异影响很小（各为4%至6%）。类似的结果，观察到1950年和1970年出生的队列，无论他们的差异，吸烟模式从1960 cohol.ConclusionsAfter考虑到吸烟，黑人肺癌死亡率较高，主要可以解释的差异，发展肺癌的风险。然而，随着肺癌治疗和检测的改善，其他因素在决定黑人和总人口之间肺癌死亡率差异方面可能变得更加重要。为了防止目前的差距进一步扩大，必须确保所有人都能公平地获得这些改善。
BackgroundLung cancer is the leading cause of cancer deaths and disproportionately affects self-identified Black or African American (“Black”) people, especially considering their relatively low self-reported smoking intensity rates. This study aimed to determine the relative impact of smoking history and lung cancer incidence risk, histology, stage, and survival on these disparities.MethodsWe used 2 lung cancer models (MichiganLung-All Races and MichiganLung-Black) to understand why Black people have higher rates of lung cancer deaths. We studied how different factors, such as smoking behaviors, cancer development, histology, stage at diagnosis, and lung cancer survival, contribute to these differences.ResultsAdjusted for smoking history, approximately 90% of the difference in lung cancer deaths between the overall and Black populations (born in 1960) was the result of differences in the risk of getting lung cancer. Differences in the histology and stage of lung cancer and survival had a small impact (4% to 6% for each). Similar results were observed for the 1950 and 1970 birth cohorts, regardless of their differences in smoking patterns from the 1960 cohort.ConclusionsAfter taking smoking into account, the higher rate of lung cancer deaths in Black people can mostly be explained by differences in the risk of developing lung cancer. As lung cancer treatments and detection improve, however, other factors may become more important in determining differences in lung cancer mortality between the Black and overall populations. To prevent current disparities from becoming worse, it is important to make sure that these improvements are available to everyone in an equitable way.