INTESTINAL ABSORPTION OF CHOLESTEROL ITS ESTERS + SOME RELATED STEROLS + ANALOGUES IN ROACH EURYCOTIS FLORIDANA
INTESTINAL ABSORPTION OF CHOLESTEROL ITS ESTERS + SOME RELATED STEROLS + ANALOGUES IN ROACH EURYCOTIS FLORIDANA
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DOI：
10.1016/0010-406x(64)90001-5
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发表时间：
1964-01-01
期刊：
影响因子：
--
通讯作者：
SMITH, DA
中科院分区：
文献类型：
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作者：
CLAYTON, RB;EDWARDS, AM;SMITH, DA
佛罗里达蟑螂肠道对胆固醇的吸收已被证明主要发生在嗉囊中，但也可能发生在胃盲肠中。在0.05-500μg的范围内，吸收的量大约与摄入的胆固醇的量成比例。酯在胆固醇肠道吸收中的作用已被研究，但仍不完全确定。然而，一些证据表明酯化不是必然的事件，尽管它可能促进低膳食浓度下的吸收。有证据表明完整的脂肪族胆固醇酯可以从肠道吸收。胆固醇、胆固醇甲醚和胆固醇氯的吸收效率与胆固醇大致相同。 Δ7-胆固醇的吸收效率更高，但β-谷甾醇、Δ4_胆固醇和表胆甾醇的吸收效率低于胆固醇。这些发现与脊椎动物的类似研究结果进行了比较。
Absorption of cholesterol from the intestinal tract of the roach, E. floridana, has been shown to occur predominantly in the crop but probably also in the gastric caeca. The amount absorbed is approximately proportional to the amount of cholesterol ingested over the range 0.05-500 [mu]g. The role of ester if ication in the intestinal absorption of cholesterol has been studied, but remains incompletely defined. However, several lines of evidence suggest that esterification is not an obligatory event, though it may facilitate absorption at low dietary concentrations. Evidence is presented for the absorption of intact aliphatic cholesteryl esters from the gut. Cholestanol, cholesteryl methyl ether and cholesteryl chloride are absorbed about as efficiently as cholesterol. [DELTA]7-Cholestenol is absorbed more efficiently, but [beta]-sitosterol,[DELTA]4_cholestenol and epicholestanol are absorbed less efficiently than cholesterol. These findings are compared with those from similar studies in vertebrates.