Lewis acid-catalyzed formation of Ugi four-component reaction product from Passerini three-component reaction system without an added amine
Lewis acid-catalyzed formation of Ugi four-component reaction product from Passerini three-component reaction system without an added amine
复制标题
路易斯酸催化帕塞里尼三组分反应体系在不添加胺的情况下形成Ugi四组分反应产物
DOI：
10.1016/j.tet.2007.10.050
复制
发表时间：
2007-12-24
期刊：
影响因子：
2.1
通讯作者：
Li, Huoming
中科院分区：
文献类型：
--
作者：
Dai, Wei-Min;Li, Huoming
In the presence of a Lewis acid the phenol-Passerini three-component reaction (phenol-P-3CR) system is found to deliver a product of the phenol-Ugi four-component reaction (phenol-U-4CR). It is the first demonstration of an isocyanide as an amine equivalent in isocyanide-based multicomponent reactions (IMCRs). In general, by using Ti(O-i-Pr)(4) in MeOH both phenol-U-4CR and U-4CR products are synthesized from an aromatic aldehyde, a phenolic or carboxylic acid, and an isocyanide. Moreover, by using MeCN as the solvent, the phenol-P-3CR products can be obtained in good yields without contamination of the phenol-U-4CR products. (c) 2007 Elsevier Ltd. All rights reserved.
