Mice lacking d-amino acid oxidase activity exhibit marked reduction of methamphetamine-induced stereotypy.
Mice lacking d-amino acid oxidase activity exhibit marked reduction of methamphetamine-induced stereotypy.
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DOI：
10.1016/j.ejphar.2008.03.031
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发表时间：
2008-05
影响因子：
5
通讯作者：
A. Hashimoto;R. Konno;Hiroshi Yano;M. Yoshikawa;Raita Tamaki;H. Matsumoto;Hiroyuki Kobayashi
中科院分区：
文献类型：
--
作者：
A. Hashimoto;R. Konno;Hiroshi Yano;M. Yoshikawa;Raita Tamaki;H. Matsumoto;Hiroyuki Kobayashi
比较甲基苯丙胺（5.0mg/kg）对D-氨基酸氧化酶活性缺失突变小鼠和正常小鼠的行为学影响。与正常小鼠相比，突变小鼠表现出甲基苯丙胺诱导的刻板性明显下降，而与正常小鼠相比，突变小鼠表现出甲基苯丙胺引起的自发活动急剧增加。由于突变小鼠脑中d-丝氨酸水平显著高于正常小鼠，因此突变小鼠脑中d-丝氨酸水平的增加可通过N-甲基-d-天冬氨酸受体拮抗甲基苯丙胺诱导的刻板行为。
The behavioral effects induced by methamphetamine (5.0 mg/kg) were compared in the mutant mice lacking d-amino acid oxidase activity and normal mice. The mutant mice exhibited marked decline in the methamphetamine-induced stereotypy compared to the normal mice, whereas the mutant mice displayed a drastic augmentation in the locomotor activity evoked by methamphetamine compared to the normal mice. Because the d-serine levels in the brain of the mutant mice are significantly higher than those in the normal mice, the enhanced d-serine in the brain of the mutant mice could antagonize the methamphetamine-induced stereotypy via the N-methyl-d-aspartate receptors.