Magnetic resonance Spectroscopy study of oxygen therapy in ischemic stroke

Magnetic resonance Spectroscopy study of oxygen therapy in ischemic stroke
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DOI：
10.1161/strokeaha.107.487280
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发表时间：
2007-10-01
期刊：
STROKE
影响因子：
8.3
通讯作者：
Gonzalez, R. Gilberto
Gonzalez, R. Gilberto
中科院分区：
医学1区
文献类型：
--
作者：
Singhal, Aneesh B.;Ratai, Eva;Gonzalez, R. Gilberto

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背景和目的-最近的研究表明，常压氧治疗（NBO）是在急性缺血性stroke.Methods神经保护我们进行了多体素磁共振波谱成像和扩散/灌注MRI与NBO或室内空气治疗中风患者。成像进行之前，期间，和之后therapeutic. Results-Voxel为基础的分析显示，在所有时间点的表观扩散系数值，乳酸，和N-乙酰天冬氨酸水平之间的良好相关性。NBO期间乳酸减少，NBO后增加。N-乙酰天冬氨酸减少在患者接受室内空气，但不是在NBO治疗patients.Conclusion -这些数据表明，NBO改善有氧代谢，并保留在缺血性脑神经元的完整性。
Background and Purpose - Recent studies suggest that normobaric oxygen therapy (NBO) is neuroprotective in acute ischemic stroke.Methods - We performed multivoxel magnetic resonance spectroscopic imaging and diffusion/perfusion MRI in patients with stroke treated with NBO or room air. Imaging was performed before, during, and after therapy.Results - Voxel-based analysis showed excellent correlation between apparent diffusion coefficient values, lactate, and N-acetyl-aspartate levels at all time points. Lactate decreased during NBO and increased post-NBO. N-acetyl-aspartate decreased in patients receiving room air but not in NBO-treated patients.Conclusion - These data suggest that NBO improves aerobic metabolism and preserves neuronal integrity in the ischemic brain.