PROGNOSTIC AND PREDICTIVE VALUE OF EZH2 EXPRESSION AND THE TUMOR IMMUNE MICROENVIRONMENT IN MERKEL CELL CARCINOMA
PROGNOSTIC AND PREDICTIVE VALUE OF EZH2 EXPRESSION AND THE TUMOR IMMUNE MICROENVIRONMENT IN MERKEL CELL CARCINOMA
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DOI：
10.5114/pjp.2021.109516
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发表时间：
2021-01-01
影响因子：
0.8
通讯作者：
Paydas, Semra
中科院分区：
文献类型：
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作者：
Acikalin, Arbil;Bagir, Emine;Paydas, Semra
默克尔细胞癌（MCC）是一种罕见且致命的皮肤癌，其特点是频繁复发和转移。鉴于 MCC 缺乏经过验证的治疗方案，我们通过免疫化学方法评估了 13 名 MCC 患者肿瘤组织制备的载玻片上默克尔细胞多瘤病毒 (MCPyV)、PD-1、PD-L1、CD8 和 EZH2 的存在，并检查了它们与疾病进展和总体生存的关系。 92.3% 的患者的肿瘤浸润淋巴细胞 (TIL) 上表达 PD-1。没有肿瘤细胞表达PD-L1。 MCPyV 阳性肿瘤中 CD8 水平较高。有趣的是，较高的 CD8 水平与较好的总生存率相关 (p = 0.025)，而较高的 EZH2 表达与转移/复发相关 (z = -1.396，p = 0.089)。然而，低 EZH2 表达与较差的总生存率相关（chi(2) = 3.745，Cramer V = 0.537，p = 0.086）。这些发现表明 EZH2 在 MCC 中发挥重要作用，可能是一个有前途的治疗靶点。
Merkel cell carcinoma (MCC) is a rare and lethal type of skin cancer characterized by frequent recurrences and metastases. In view of the lack of a proven treatment option for MCC, we immunochemically evaluated the presence of Merkel cell polyomavirus (MCPyV), PD-1, PD-L1, CD8, and EZH2 on slides prepared from tumor tissues of 13 patients with MCC, and examined their association with disease progression and overall survival. PD-1 was expressed on tumor infiltrating lymphocytes (TILs) in 92.3% of the patients. None of the tumor cells expressed PD-L1. CD8 levels were higher in MCPyV-positive tumors. Interestingly, higher CD8 levels correlated with better overall survival (p = 0.025), while higher EZH2 expression correlated with metastasis/recurrence (z = -1.396, p = 0.089). However, low EZH2 expression was associated with poor overall survival (chi(2) = 3.745, Cramer V = 0.537, p = 0.086). These findings suggest that EZH2 plays a significant role in MCC and may be a promising therapeutic target.