Involvement of the nucleus accumbens and medial prefrontal cortex in the expression of conditioned hyperactivity to a cocaine-associated environment in rats
Involvement of the nucleus accumbens and medial prefrontal cortex in the expression of conditioned hyperactivity to a cocaine-associated environment in rats
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DOI：
10.1016/s0893-133x(00)00162-7
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发表时间：
2000-12-01
影响因子：
7.6
通讯作者：
Druhan, JP
中科院分区：
文献类型：
--
作者：
Franklin, TR;Druhan, JP
本研究探讨了伏隔核（NAc）、内侧前额叶皮层、基底外侧杏仁核和海马腹侧下托在对可卡因相关刺激的巴甫洛夫条件性多动反应表达中的作用。这是通过在先前与可卡因相关的环境中进行条件性多动的无药物测试之前通过药理学抑制这些区域来实现的。结果表明，条件性多动可以通过将 GABA-B 激动剂巴氯芬（0.2 nmol/0.5 μl/侧）输注到 NAc 中来破坏，或者通过将 GABA-A 激动剂蝇蕈醇（0.1 和 0.2 nmol/0.5 μl/侧）输注到内侧前额皮质中来完全阻断。相比之下，条件性多动不受基底外侧杏仁核、腹侧下托或 NAc 或前额叶皮层背侧部位的药物抑制的影响。这些发现表明，NAc 和前额皮质是对可卡因相关刺激表达巴甫洛夫条件反应的神经回路的关键元件。 (C) 2000 年美国神经精神药理学学院。由爱思唯尔科学公司出版
This study examined the roles of the nucleus accumbens (NAc), medial prefrontal cortex, basolateral amygdala, and ventral subiculum of the hippocampus in the expression of Pavlovian conditioned hyperactivity responses to cocaine-related stimuli. This was accomplished by pharmacologically inhibiting these regions prior to drug-free tests for conditioned hyperactivity in an environment previously associated with cocaine. The results indicate that conditioned hyperactivity could be disrupted by infusions of the GABA-B agonist, baclofen (0.2 nmol/0.5 mul/side) into the NAc, or completely blocked by infusions of the GABA-A agonist, muscimol (0.1 and 0.2 nmol/0.5 mul/side) into the medial prefrontal cortex. In contrast, conditioned hyperactivity was unaffected by pharmacological inhibition of the basolateral amygdala, the ventral subiculum, or sites dorsal to the NAc or prefrontal cortex. These findings suggest that the NAc and the prefrontal cortex are crucial elements of the neural circuitry underlying the expression of Pavlovian conditioned responses to cocaine-related stimuli. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.