A novel MMP-responsive nanoplatform with transformable magnetic resonance property for quantitative tumor bioimaging and synergetic chemo-photothermal therapy
A novel MMP-responsive nanoplatform with transformable magnetic resonance property for quantitative tumor bioimaging and synergetic chemo-photothermal therapy
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DOI：
10.1016/j.nantod.2022.101524
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发表时间：
2022-06-15
期刊：
影响因子：
17.4
通讯作者：
Wang, Zhongling
中科院分区：
文献类型：
--
作者：
Chen, An;Lu, Hongwei;Wang, Zhongling
通过非侵入性方法定量肿瘤微环境中的生物靶向标记物仍然具有挑战性。本研究设计了一种新型的基质金属蛋白酶9（MMP 9）响应性纳米平台（PMP@USPIO/DOX，PMPSD），该平台具有可变换的磁共振特性，可用于定量肿瘤生物成像和协同化疗光热治疗。由于超小超顺磁性氧化铁（USPIO）聚集状态，纳米平台在生理条件下充当T-2造影剂，而在肿瘤微环境中，纳米簇被MMP 9解离，从而将纳米平台转化为T-1造影剂。利用T1、T2加权像和T1、T2图定量研究MRI信号变化与MMP 9浓度的相关性，并评价MMP 9活性。此外，PMP@USPIO/DOX纳米平台具有优异的光热性能。PMPSD联合激光照射比单纯化疗/光热治疗更有效，上调肿瘤中MMP 9水平可进一步提高治疗效果。该纳米平台在评估疾病预后和无创监测药物释放方面具有重要意义。该概念为肿瘤微环境的非侵入性定量研究提供了一种新的思路。(c)2022爱思唯尔有限公司版权所有。
Quantifying bio-targeted markers in the tumor microenvironment through non-invasive approaches remains challenging. In this study, a novel matrix metalloproteinase-9 (MMP9) responsive nanoplatform (PMP@USPIO/DOX, PMPSD) with transformable magnetic resonance property is designed for quantitative tumor bioimaging and synergetic chemo-photothermal therapy. The nanoplatform acts as a T-2 contrast agent in physiological conditions due to the ultrasmall superparamagnetic iron oxide (USPIO) aggregation state, whereas in the tumor microenvironment, the nanoclusters are dissociated by MMP9, thus transforming the nanoplatform into a T-1 contrast agent. T-1 & T-2 weighted image and T-1 & T-2 maps are utilized to quantitatively study the correlation between MRI signal changes and MMP9 concentrations and to evaluate MMP9 activity. In addition, the PMP@USPIO/DOX nanoplatform possesses excellent photothermal properties. PMPSD combined with laser irradiation is more effective than single chemo-/photothermal therapy, and up-regulation of the MMP9 level in the tumor can further improve the therapeutic effect. The nano platform is of great significance in evaluating disease prognosis and non-invasive monitoring of drug release. The concept reported here provides a creative idea for the non-invasive quantitative study of the tumor microenvironment. (c) 2022 Elsevier Ltd. All rights reserved.