Addressing the Challenges of Pathogen Evolution on the World's Arable Crops
Addressing the Challenges of Pathogen Evolution on the World's Arable Crops
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DOI：
10.1094/phyto-01-16-0036-fi
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发表时间：
2016-10-01
期刊：
影响因子：
3.2
通讯作者：
Thrall, Peter H.
中科院分区：
文献类型：
--
作者：
Burdon, Jeremy J.;Zhan, Jiasui;Thrall, Peter H.
基因组和分子技术的进步，加上对许多抗性和感染性基因的精细结构的日益了解，为控制许多植物病原体开辟了一个新的希望时代，这些病原体仍然是可耕地作物损失的主要来源。一些新的方法正在考虑中，包括使用非宿主抗性和针对关键的发展制约因素。然而，这些基因组和分子方法的主要目的是增强抗性基因的鉴定，通过标记和基因编辑技术增加其操作的容易性，并将一系列抗性基因锁定在简单可操作的抗性基因盒中。所有这些方法基本上都延续了一种策略，即假设有能力构建靶向病原体无法克服的基于遗传的抗性屏障。在这里，我们展示了知识和标记技术的最新进展如何用于产生更持久的抗病策略，这些策略基于广泛的进化原则，旨在为病原体提供一个不断变化的，波动的定向选择景观。
Advances in genomic and molecular technologies coupled with an increasing understanding of the fine structure of many resistance and infectivity genes, have opened up a new era of hope in controlling the many plant pathogens that continue to be a major source of loss in arable crops. Some new approaches are under consideration including the use of nonhost resistance and the targeting of critical developmental constraints. However, the major thrust of these genomic and molecular approaches is to enhance the identification of resistance genes, to increase their ease of manipulation through marker and gene editing technologies and to lock a range of resistance genes together in simply manipulable resistance gene cassettes. All these approaches essentially continue a strategy that assumes the ability to construct genetic-based resistance barriers that are insurmountable to target pathogens. Here we show how the recent advances in knowledge and marker technologies can be used to generate more durable disease resistance strategies that are based on broad evolutionary principles aimed at presenting pathogens with a shifting, landscape of fluctuating directional selection.