A Rapid Self-Pumping Organohydrogel Dressing with Hydrophilic Fractal Microchannels to Promote Burn Wound Healing
A Rapid Self-Pumping Organohydrogel Dressing with Hydrophilic Fractal Microchannels to Promote Burn Wound Healing
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DOI：
10.1002/adma.202301765
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发表时间：
2023-07-30
影响因子：
29.4
通讯作者：
Wang, Shutao
中科院分区：
文献类型：
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作者：
Lan, Jinze;Shi, Lianxin;Wang, Shutao
烧伤创面肿胀组织和水疱过度分泌的大量渗出物严重延缓创面愈合，给传统敷料带来了巨大挑战。本文报道了一种具有亲水性分形微通道的自泵式有机水凝胶敷料，与纯水凝胶相比，其可以快速排出过量渗出液，效率提高约30倍，并有效促进烧伤创面愈合。提出了一种乳化-辅助乳液界面聚合方法，通过有机凝胶前体液滴的动态漂浮-碰撞-聚结过程，在自泵性有机水凝胶中形成亲水性分形水凝胶微通道。在小鼠烧伤创面模型中，与市售敷料（Tegadidine）相比，快速自泵式有机水凝胶敷料可显著减少真皮腔约42.5%，加速血管再生约6.6倍，毛囊再生约13.5倍。该研究为设计高性能功能性烧伤创面敷料提供了一条途径。
Burn wounds pose great challenges for conventional dressings because massive exudates oversecreted from swollen tissues and blisters seriously delay wound healing. Herein, a self-pumping organohydrogel dressing with hydrophilic fractal microchannels is reported that can rapidly drain excessive exudates with approximate to 30 times enhancement in efficiency compared with the pure hydrogel, and effectively promote burn wound healing. A creaming-assistant emulsion interfacial polymerization approach is proposed to create the hydrophilic fractal hydrogel microchannels in the self-pumping organohydrogel through a dynamic floating-colliding-coalescing process of organogel precursor droplets. In a murine burn wound model, the rapid self-pumping organohydrogel dressings can markedly reduce dermal cavity by approximate to 42.5%, accelerate blood vessel regeneration by approximate to 6.6 times, and hair follicle regeneration by approximate to 13.5 times, compared with the commercial dressing (Tegaderm). This study paves an avenue for designing high-performance functional burn wound dressings.