The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet
The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet
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DOI：
10.1113/jphysiol.2010.191767
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发表时间：
2010-09-01
影响因子：
5.5
通讯作者：
Ashcroft, Frances M.
中科院分区：
文献类型：
--
作者：
McTaggart, James S.;Clark, Rebecca H.;Ashcroft, Frances M.
三磷酸腺苷敏感钾(K-ATP)通道是维持血糖稳态的关键。它们是葡萄糖刺激的胰岛β细胞分泌胰岛素所必需的，参与低血糖刺激胰岛α细胞释放胰高血糖素的机制，并参与骨骼肌对葡萄糖的摄取、肝脏葡萄糖的产生和释放以及摄食行为。不足为奇的是，K-ATP通道基因的功能缺失或功能增强突变具有深远的影响，分别导致先天性高胰岛素血症和新生儿糖尿病。本次研讨会的综述集中于我们目前对K-ATP通道在健康和疾病中葡萄糖稳态中的作用的了解。
ATP-sensitive potassium (K-ATP) channels are critical for the maintenance of glucose homeostasis. They are essential for glucose-stimulated insulin secretion from pancreatic beta-cells, contribute to the mechanisms by which hypoglycaemia stimulates glucagon release from pancreatic alpha-cells, and are involved in glucose uptake into skeletal muscle, glucose production and release from the liver, and feeding behaviour. Not surprisingly, loss- or gain-of-function mutations in K-ATP channel genes have profound effects, giving rise to congenital hyperinsulinaemia and neonatal diabetes respectively. This symposium review focuses on our current understanding of the role of the K-ATP channel in glucose homeostasis in health and disease.