DIELECTRIC EFFECTS IN BIO-POLYMERS - THE THEORY OF IONIC SATURATION REVISITED
DIELECTRIC EFFECTS IN BIO-POLYMERS - THE THEORY OF IONIC SATURATION REVISITED
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DOI：
10.1002/bip.360240302
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发表时间：
1985-01-01
期刊：
影响因子：
2.9
通讯作者：
TURNER, JE
中科院分区：
文献类型：
--
作者：
HINGERTY, BE;RITCHIE, RH;TURNER, JE
静电效应被认为在许多方面决定了大分子的分子结构和功能。在金属基酶和溶液中金属-大分子相互作用中，这些效应可能占主导地位。为了从理论上解决金属离子-核酸相互作用，提出了对50多年前首次提出的德拜距离依赖介电函数的修改。这个函数更接近于原子间小间距的物理现实。这一理论得到的介电函数在初步计算中与实验数据有较好的一致性。
Electrostatic effects are believed to determine the molecular structure and function of macromolecules in many ways. In metallo-based enzymes and in metal-macromolecule interactions in solution, these effects may predominate. To tackle metal ion-nucleic acid interactions theoretically, a modification of Debye''s distance-dependent dielectric function first proposed more than 50 years ago is proposed. This function more closely approximates physical reality at small interatomic separations. This theory yields a dielectric function that gives reasonable agreement with experimental data in preliminary calculations.