Direct assessment of small airways reactivity in human subjects.
Direct assessment of small airways reactivity in human subjects.
复制标题
直接评估人类受试者的小气道反应性。
DOI：
--
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发表时间：
1998
影响因子：
24.7
通讯作者：
Mark C. Liu
中科院分区：
文献类型：
--
作者：
Elizabeth M. Wagner;E. Bleecker;E. Bleecker;S. Permutt;Mark C. Liu
Our knowledge of airways reactivity to inflammatory agonists is derived predominantly from tests dominated by large airway responsiveness. To determine directly, the histamine responsiveness of the smallest airways, eight normal and 11 asymptomatic asthmatic subjects were studied utilizing a wedged bronchoscope technique. A fiberoptic bronchoscope was wedged in the anterior segment of the right upper lobe and a double-lumen catheter was advanced through the working channel to its tip. With a constant flow of gas (5% CO2 in air) through one lumen of the catheter, pressure at the tip of the bronchoscope was measured with the subject breath-holding at FRC. Peripheral airways resistance (Rp) was measured at baseline and after saline, histamine (10, 50, 100 mg/ml) and isoproterenol (2 mg/ml) challenge through the bronchoscope. Baseline Rp of asthmatics (0.041 +/- 0.015 cm H2O/ml/min; mean +/- SE) was significantly greater than normal subjects (0.011 +/- 0.003 cm H2O/ml/min; p = 0.019). The log of the concentration of histamine that caused a 100% increase in peripheral airways response was greater in the normal subjects than in the asthmatic subjects (p = 0.0114) and correlated with whole lung responsiveness to histamine in asthmatics (r = 0.847, p < 0.05). Isoproterenol reversed completely the increase in Rp in normal subjects but not asthmatic subjects. The results of this study demonstrate that the resistance of the smallest peripheral airways, when measured directly, increased when challenged locally with histamine in both normal subjects and asthmatic subjects. However, the peripheral airways responsiveness was significantly enhanced in asthmatic subjects relative to normal controls.
人体臭氧暴露：炎症、小气道和外周气道反应。
DOI：
10.1164/ajrccm.152.4.7551367
发表时间：
1995
期刊：
American journal of respiratory and critical care medicine.
影响因子：
--
作者：
Weinmann,GG;Liu,MC;Proud,D;Weidenbach-Gerbase,M;Hubbard,W;Frank,R
通讯作者：
Frank,R