Environmental tobacco smoke and cardiometabolic risk in young children: results from a survey in south-west Germany
Environmental tobacco smoke and cardiometabolic risk in young children: results from a survey in south-west Germany
复制标题
DOI：
10.1093/eurheartj/ehp180
复制
发表时间：
2009-08-01
影响因子：
39.3
通讯作者：
Koenig, Wolfgang
中科院分区：
文献类型：
--
作者：
Nagel, Gabriele;Arnold, Frank J.;Koenig, Wolfgang
本研究以10岁儿童为研究对象，采用横断面研究方法，探讨环境烟草烟雾（ETS）暴露与各种心脏代谢生物标志物之间的关系。通过家长问卷收集ETS暴露和潜在混杂因素的数据。测定脂联素、瘦素、炎症标志物、载脂蛋白（apo）AI和B以及脂蛋白相关磷脂酶A（2）（Lp-PLA（2））。使用第90百分位数作为截止点，应用线性和逻辑回归模型，脂联素和apoAI（第10百分位数）除外。在线性模型中，ETS暴露与瘦素、C反应蛋白、纤维蛋白原、白细胞介素（IL）-6和Lp-PLA的血浆浓度增加显著相关（2）。与无吸烟者相比，每天吸烟超过10支的ETS暴露与瘦素浓度升高有关（OR 6.40; 95% CI，2.67-15.39），C反应蛋白（OR 3.17; 95%CI，1.31-7.68），Lp-PLA（2）（OR 2.97 95%CI，1.32-6.68），低脂联素（OR 2.69; 95%CI，1.10-6.57）和低apoAI（OR 4.48; 95%CI，2.16-10.85）。暴露于ETS的剂量增加与异常心脏代谢标志物数量增加有关。在儿童中，暴露于ETS与低度炎症反应和脂质代谢标志物改变有关，这可能会在早期引发动脉粥样硬化。然而，纵向研究是必要的，以确定这些协会的潜在因果关系。
We explored the association between exposure to environmental tobacco smoke (ETS) and various cardiometabolic biomarkers in 10-year-old children.A population-based cross-sectional study was carried out. Data on ETS exposure and potential confounders were collected by parental questionnaire. Adiponectin, leptin, markers of inflammation, apolipoproteins (apo) AI and B, and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) were measured. Linear and logistic regression models were applied using the 90th percentile as a cut-off point except for adiponectin and apoAI (10th percentile). In linear models, ETS exposure was significantly associated with increasing plasma concentrations of leptin, C-reactive protein, fibrinogen, interleukin (IL)-6, and Lp-PLA(2). When compared with none, ETS exposure of more than 10 cigarettes per day was associated with elevated concentrations of leptin (OR 6.40; 95% CI, 2.67-15.39), C-reactive protein (OR 3.17; 95% CI, 1.31-7.68), Lp-PLA(2) (OR 2.97 95% CI, 1.32-6.68), low adiponectin (OR 2.69; 95% CI, 1.10-6.57), and low apoAI (OR 4.48; 95% CI, 2.16-10.85). Increasing dose of ETS exposure was related to an increasing number of abnormal cardiometabolic markers.Among children, ETS exposure was associated with a low-grade inflammatory response and altered markers of lipid metabolism, which may initiate atherosclerosis in early life. However, longitudinal studies are necessary to determine the potential causal relevance of these associations.