Analysis of the distribution of binding sites for the plant lectin Bandeiraea simplicifolia I-isolectin B4 on primary sensory neurones in seven mammalian species
Analysis of the distribution of binding sites for the plant lectin Bandeiraea simplicifolia I-isolectin B4 on primary sensory neurones in seven mammalian species
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DOI：
10.1002/ar.10144
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发表时间：
2002-10-01
影响因子：
--
通讯作者：
Plenderleith, MB
中科院分区：
文献类型：
--
作者：
Gerke, MB;Plenderleith, MB
研究植物凝集素Bandeiraea simplicifolia I-isolectin B-4（BSI-B-4）与7种哺乳动物感觉神经元的结合模式。采用凝集素组织化学法对三种大鼠、小鼠、豚鼠、兔、狐蝠、猫和绒猴的背根神经节和脊髓进行BSI-B-4筛选。BSI-B-4结合与索马的主要是小直径的初级感觉神经元在背根神经节和它们的轴突终末内板层I和II的浅背角在所有7个物种。在这些物种中的每一个中的凝集素结合模式的相似性表明，BSI-B-4结合的糖缀合物在哺乳动物中具有普遍存在的分布，并支持该凝集素可能优先结合到在这些物种中的每一个中具有相似功能作用的感觉神经元的亚群的提议。
The purpose of the present study was to investigate the binding patterns of the plant lectin Bandeiraea simplicifolia I-isolectin B-4 (BSI-B-4) to sensory neurones in seven mammalian species. The dorsal root ganglia and spinal cords of three rats, mice, guinea pigs, rabbits, flying foxes, cats, and marmoset monkeys were screened for BSI-B-4 using lectin histochemistry. BSI-B-4 binding was associated with the soma of predominantly small-diameter primary sensory neurones in the dorsal root ganglia and their axon terminals within laminae I and II of the superficial dorsal horn in all seven species. The similarities of lectin binding patterns in each of these species suggest that the glycoconjugate to which BSI-B-4 binds has a ubiquitous distribution in mammals, and supports the proposal that this lectin may preferentially bind to a subpopulation of sensory neurones with a similar functional role in each of these species.