The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging
The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging
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DOI：
10.3389/fnagi.2020.00041
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发表时间：
2020-02-28
影响因子：
4.8
通讯作者：
Kuwabara, Satoshi
中科院分区：
文献类型：
--
作者：
Li, Hongliang;Hirano, Shigeki;Kuwabara, Satoshi
认知功能和纹状体多巴胺功能在正常衰老过程中都会下降。然而，这三个因素之间的关系仍然不清楚。本研究的目的是阐明健康受试者纹状体多巴胺转运体（DAT）的年龄相关变化与认知功能之间的关系。30名健康志愿者入组本研究，年龄范围为41 - 82岁（64.5 ± 11.5，平均值± SD）。所有受试者均接受T1加权磁共振成像（MRI）和I-123-FP-CIT单光子发射计算机断层扫描（SPECT）图像扫描。采用韦氏成人智力量表第三版（WAIS-III）评定认知功能。在MRI图像上手工绘制尾状核、前壳核和后壳核上直径为10 mm的6个球形感兴趣区（ROI），并将其应用于SPECT图像。采用多元回归分析方法分析纹状体枕叶比值（SOR）与WAIS-III量表分的关系。对有统计学意义的子分进行通径分析。全智商（IQ）、言语智商（verbal IQ）、言语理解（verbal comprehension）均与年龄调整后的纹状体DAT结合率正相关（P < 0.01）。多元回归分析显示，编码数字符号与除左尾状核外的所有纹状体区相关（P < 0.04）。图片完整度与右侧尾状核、相似度与左侧尾状核也呈显著正相关（P < 0.04）。通径分析发现，右侧尾状核与图片完整性、左侧尾状核与相似性之间存在独立的年龄相关，而编码数字符号的模型不显著。这些结果表明，纹状体DAT结合的年龄为基础的个体多样性与言语功能，尾状核在这种关联中起着重要作用。
Both cognitive function and striatal dopamine function decline by normal aging. However, the relationship among these three factors remains unclear. The aim of this study was to elucidate the association among age-related changes in the striatal dopamine transporter (DAT) and cognitive function in healthy subjects. The 30 healthy volunteers were enrolled in this research, the age ranged from 41 to 82 (64.5 +/- 11.5, mean +/- SD). All subjects were scanned with both T1-weighted magnetic resonance imaging (MRI) and I-123-FP-CIT single-photon emission computed tomography (SPECT) images. The Wechsler Adult Intelligence Scale-Third Edition (WAIS-III) was used to evaluate cognitive function. Six spherical regions of interest (ROI) using 10 mm in diameter on the caudate nucleus, anterior putamen and posterior putamen were manually drawn on MRI image which was applied onto SPECT image. The relationship between striatal occipital ratio (SOR) values and WAIS-III subscore were analyzed by multiple regression analysis. Subscores which was significant were further analyzed by path analyses. Full intelligence quotient (IQ), verbal IQ, verbal comprehension were all positively correlated with age-adjusted striatal DAT binding (P < 0.01). Multiple regression analyses revealed that the coding digit symbol correlated with all striatal regions except for the left caudate (P < 0.04). Picture completion and right caudate, similarities and left caudate also showed a positive correlation (P < 0.04). Path analysis found that the right caudate and picture completion; the left caudate and similarities were correlated independently from age, whereas the models of coding digit symbol were not significant. These results suggest that age-based individual diversity of striatal DAT binding was associated with verbal function, and the caudate nucleus plays an important role in this association.