Estrogen-IGF-1 interactions in neuroprotection: ischemic stroke as a case study.
Estrogen-IGF-1 interactions in neuroprotection: ischemic stroke as a case study.
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DOI：
10.1016/j.yfrne.2014.05.003
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发表时间：
2015-01
影响因子：
7.4
通讯作者：
Sohrabji, Farida
中科院分区：
文献类型：
--
作者：
Sohrabji, Farida
The steroid hormone 17b-estradiol and the peptide hormone insulin-like growth factor (IGF)-1 independently exert neuroprotective actions in neurologic diseases such as stroke. Only a few studies have directly addressed the interaction between the two hormone systems, however, there is a large literature that indicates potentially greater interactions between the 17b-estradiol and IGF-1 systems. The present review focuses on key issues related to this interaction including IGF-1 and sex differences and common activation of second messenger systems. Using ischemic stroke as a case study, this review also focuses on independent and cooperative actions of estrogen and IGF-1 on neuroprotection, blood brain barrier integrity, angiogenesis, inflammation and post-stroke epilepsy. Finally, the review also focuses on the astrocyte, a key mediator of post stroke repair, as a local source of 17b-estradiol and IGF-1. This review thus highlights areas where significant new research is needed to clarify the interactions between these two neuroprotectants.
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影响因子：
9.3
作者：
Bellini MJ;Hereñú CB;Goya RG;Garcia-Segura LM
通讯作者：
Garcia-Segura LM
DOI：
10.1016/s0960-0760(02)00261-3
发表时间：
2002-12-01
影响因子：
4.1
作者：
Cardona-Gómez, GP;Mendez, P;Garcia-Segura, LM
通讯作者：
Garcia-Segura, LM
影响因子：
5.9
作者：
BAR, RS;BOES, M;SANDRA, A
通讯作者：
SANDRA, A
影响因子：
3.1
作者：
Arthur, WT;Vernon, RB;Reed, MJ
通讯作者：
Reed, MJ
DOI：
10.1016/j.jsbmb.2005.02.016
发表时间：
2005-06-01
影响因子：
4.1
作者：
Carswell, HVO;Dominiczak, AF;Macrae, IM
通讯作者：
Macrae, IM